{"id":"W2912558782","doi":"10.1038/s41388-019-0725-6","title":"PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells","year":2019,"lang":"en","type":"article","venue":"Oncogene","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Deutsche Krebshilfe; National Pancreas Foundation; American Gastroenterological Association; National Cancer Institute; U.S. Department of Health and Human Services; Fonds de Recherche du Québec - Santé; Foundation for the National Institutes of Health","keywords":"Biology; FOXM1; Pancreatic cancer; Cancer research; Transcription factor; Epithelial–mesenchymal transition; DNA damage; Cell biology; Cancer cell; Gene isoform; Metastasis; Carcinogenesis; Cancer; Gene; Genetics; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002876214,0.0003442969,0.0003277267,0.000350823,0.0003639494,0.0005423923,0.0003458284,0.0003219681,0.002040185],"category_scores_gemma":[0.0001636479,0.000271189,0.0004549162,0.0003372118,0.0003795627,0.0004929223,0.0004584105,0.0006794931,0.0006094708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006182884,"about_ca_system_score_gemma":0.0002895937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007342233,"about_ca_topic_score_gemma":0.001020401,"domain_scores_codex":[0.9997382,0.00003273183,0.00002237893,0.00007767752,0.00006100549,0.00006799932],"domain_scores_gemma":[0.9998534,0.00001381768,0.00004862172,0.0000326466,0.00001436118,0.00003719185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001894885,0.00001628092,0.0007105342,0.00003639425,0.0000084268,0.00008049361,0.00002700642,0.00005678885,0.9972174,0.0003348978,0.0001117826,0.001210451],"study_design_scores_gemma":[0.00003470864,0.000108859,0.01391983,0.000007093576,0.00002236182,0.0004359627,0.0001104671,0.0009625129,0.9778169,0.0001383025,0.006436816,0.000006124599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989839,0.003158228,0.003321571,0.0004695299,0.00005889385,0.00001670879,0.0005504107,0.0001544697,0.002431274],"genre_scores_gemma":[0.9895781,0.0009609505,0.001766987,0.00009070093,0.00001272565,0.00002300051,0.0008511419,0.00004274776,0.006673631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040185,"threshold_uncertainty_score":0.006825089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006755115745812328,"score_gpt":0.2351322543161581,"score_spread":0.2283771385703458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}