{"id":"W2912569791","doi":"10.1016/j.mce.2019.01.026","title":"Regulation of Gpr173 expression, a putative phoenixin receptor, by saturated fatty acid palmitate and endocrine-disrupting chemical bisphenol A through a p38-mediated mechanism in immortalized hypothalamic neurons","year":2019,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Dutch Dairymen Board","keywords":"CREB; Endocrinology; Internal medicine; Hypothalamus; Biology; p38 mitogen-activated protein kinases; Receptor; Palmitic acid; Endocrine system; Protein kinase A; MAPK/ERK pathway; Chemistry; Fatty acid; Phosphorylation; Cell biology; Hormone; Biochemistry; Gene; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001333087,0.0004029282,0.0009101807,0.000202387,0.00004061762,0.00001554927,0.0001149282,0.0001679136,0.00006928611],"category_scores_gemma":[0.0003238246,0.0003752199,0.0001144924,0.000300256,0.0002450331,0.0001357893,0.0001731581,0.0004425632,0.00001306148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005497886,"about_ca_system_score_gemma":0.00005992355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001345883,"about_ca_topic_score_gemma":0.000002798661,"domain_scores_codex":[0.99722,0.0003058088,0.0006397269,0.000940304,0.0002823865,0.0006117474],"domain_scores_gemma":[0.9988692,0.0001305747,0.0002838828,0.00045757,0.0001446979,0.000114047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005759494,0.000153145,0.00251904,0.0001144023,0.0001344535,0.0002500217,0.0007573045,0.000003925564,0.9937385,0.0004827421,0.00001547559,0.001255044],"study_design_scores_gemma":[0.006725981,0.0003507003,0.00374858,0.00008186113,0.000114965,0.000399164,0.0004386743,0.0004663846,0.9861051,0.001093241,0.0001788437,0.0002964789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917699,0.004027238,0.001960546,0.0006280618,0.0001045128,0.001181818,0.00003196722,0.0000751102,0.0002208403],"genre_scores_gemma":[0.9962428,0.0001987306,0.002947965,0.0001215548,0.00001933551,0.00007861425,0.0002333642,0.00006316503,0.00009452685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007633369,"threshold_uncertainty_score":0.99987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007368918071939129,"score_gpt":0.229038935675254,"score_spread":0.2216700176033148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}