{"id":"W2912569791","doi":"10.1016/j.mce.2019.01.026","title":"Regulation of Gpr173 expression, a putative phoenixin receptor, by saturated fatty acid palmitate and endocrine-disrupting chemical bisphenol A through a p38-mediated mechanism in immortalized hypothalamic neurons","year":2019,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Dutch Dairymen Board","keywords":"CREB; Endocrinology; Internal medicine; Hypothalamus; Biology; p38 mitogen-activated protein kinases; Receptor; Palmitic acid; Endocrine system; Protein kinase A; MAPK/ERK pathway; Chemistry; Fatty acid; Phosphorylation; Cell biology; Hormone; Biochemistry; Gene; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807861,0.0002473557,0.0002598104,0.000277895,0.0003162852,0.0003034923,0.0002293569,0.0001873892,0.001570744],"category_scores_gemma":[0.0001251466,0.0001903349,0.0005183122,0.0002656927,0.0004025303,0.0003764112,0.0002644501,0.000785724,0.0003552205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003224531,"about_ca_system_score_gemma":0.000314313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001191922,"about_ca_topic_score_gemma":0.001369178,"domain_scores_codex":[0.9997638,0.00002440749,0.00002825284,0.00004807131,0.00004341522,0.00009215165],"domain_scores_gemma":[0.9999228,0.00001599919,0.00001473826,0.00001616364,0.00001054242,0.00001976978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004508941,0.00004916565,0.0002499492,0.00002562779,0.000009312119,0.0001325323,0.00007208539,0.00004827249,0.997838,0.0002408959,0.00004875188,0.0008345182],"study_design_scores_gemma":[0.00004814343,0.0001913652,0.006041149,0.000004643565,0.00002461516,0.0002633617,0.0001842055,0.0008297842,0.9902161,0.0001685904,0.002021624,0.000006373921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956924,0.0005116582,0.002137158,0.0001246103,0.00005494457,0.00001640981,0.0006244235,0.00003269658,0.0008057362],"genre_scores_gemma":[0.992717,0.0007079984,0.001794735,0.00005982029,0.0000153629,0.00006834526,0.001199598,0.00002011356,0.003416828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570744,"threshold_uncertainty_score":0.005254626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007368918071939129,"score_gpt":0.229038935675254,"score_spread":0.2216700176033148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}