{"id":"W2912587692","doi":"10.1007/s12079-019-00508-8","title":"TGF-β1 and TNF-α synergistically induce epithelial to mesenchymal transition of breast cancer cells by enhancing TAK1 activation","year":2019,"lang":"en","type":"article","venue":"Journal of Cell Communication and Signaling","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Applied Basic Research Key Project of Yunnan; Hubei University; National Natural Science Foundation of China; University of Alberta","keywords":"Epithelial–mesenchymal transition; MAPK/ERK pathway; Cancer research; Signal transduction; Transforming growth factor; p38 mitogen-activated protein kinases; Tumor necrosis factor alpha; Breast cancer; Slug; Cancer cell; Cell biology; Chemistry; Cancer; Medicine; Biology; Immunology; Metastasis; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090987,0.0005509087,0.0004814113,0.0003135244,0.0001571616,0.0002320339,0.0001495896,0.000207493,0.001708751],"category_scores_gemma":[0.0001102588,0.0001663538,0.0006801731,0.00020442,0.0001418808,0.0002096097,0.0003080381,0.0007844854,0.0005270105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595186,"about_ca_system_score_gemma":0.0001961269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002019295,"about_ca_topic_score_gemma":0.0004015698,"domain_scores_codex":[0.9997436,0.00005717221,0.00003402351,0.00003028631,0.00005587915,0.00007909066],"domain_scores_gemma":[0.9999126,0.00001308989,0.00002750205,0.000008847263,0.00001158222,0.0000263403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000440133,0.0001282734,0.0002093621,0.0002140427,0.00001822546,0.0000855448,0.00003113452,0.00006834459,0.995505,0.00005316625,0.0001069046,0.003139772],"study_design_scores_gemma":[0.00008224913,0.00174869,0.005198769,0.00002322873,0.00006089075,0.000595334,0.00007898576,0.001110986,0.9869315,0.00007234922,0.004087425,0.00000951473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801281,0.01160909,0.003803913,0.0003390585,0.0002918844,0.000111841,0.000401446,0.0001278922,0.003186852],"genre_scores_gemma":[0.9892429,0.004223869,0.003615193,0.0001812094,0.00006630981,0.0001075703,0.0005198739,0.00001204219,0.002030972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708751,"threshold_uncertainty_score":0.005716324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019787143754903,"score_gpt":0.2596328612098614,"score_spread":0.2494349897723124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}