{"id":"W2912602935","doi":"10.1038/s41598-018-38452-z","title":"Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Specialized Research Fund for the Doctoral Program of Higher Education of China; National Natural Science Foundation of China","keywords":"Pregnane X receptor; Medicine; Pharmacology; Single-nucleotide polymorphism; Ethambutol; Haplotype; Isoniazid; Pyrazinamide; Population; Tuberculosis; Genotype; Genetics; Biology; Gene; Environmental health; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003337837,0.0002181684,0.0002942457,0.0003161122,0.0001662376,0.0002569444,0.0001474028,0.0002191226,0.001583408],"category_scores_gemma":[0.0006185144,0.0001480746,0.000296626,0.0003578702,0.0001706342,0.0001058559,0.0001396772,0.0002370885,0.0001242551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038847,"about_ca_system_score_gemma":0.0001557948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552796,"about_ca_topic_score_gemma":0.00133754,"domain_scores_codex":[0.9997768,0.00007530763,0.00002687354,0.00005046734,0.00003693773,0.00003364909],"domain_scores_gemma":[0.9996198,0.00008943671,0.0001593684,0.00003615138,0.00003101829,0.00006419212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007875456,0.0001031198,0.9886001,0.00003038353,0.0001802478,0.000549196,0.00008505043,0.00006530945,0.005513579,0.00006154658,0.0000484556,0.003975433],"study_design_scores_gemma":[0.000020548,0.0002389517,0.9976115,0.000004795828,0.0001087142,0.0009643934,0.00003831837,0.0002989313,0.0004992011,0.0000434654,0.000168356,0.000002707873],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993499,0.0003324295,0.00006914059,0.00002117398,0.000002393283,0.000003318163,0.00003609047,0.000001472742,0.000184213],"genre_scores_gemma":[0.9996747,0.00009334239,0.00003739218,0.0000077902,0.000004992984,0.000002207958,0.00003547675,5.444468e-7,0.0001436231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583408,"threshold_uncertainty_score":0.005297005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0451432210386106,"score_gpt":0.3444397382877752,"score_spread":0.2992965172491646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}