{"id":"W2912602935","doi":"10.1038/s41598-018-38452-z","title":"Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Specialized Research Fund for the Doctoral Program of Higher Education of China; National Natural Science Foundation of China","keywords":"Pregnane X receptor; Medicine; Pharmacology; Single-nucleotide polymorphism; Ethambutol; Haplotype; Isoniazid; Pyrazinamide; Population; Tuberculosis; Genotype; Genetics; Biology; Gene; Environmental health; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003553018,0.0001927999,0.0003485551,0.0002226157,0.000391764,0.00008376055,0.0000872442,0.0003682062,0.0003348015],"category_scores_gemma":[0.0001921954,0.0001934748,0.00008388568,0.0003945427,0.0001680083,0.0002960951,0.000108714,0.0004828378,0.00003243521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001088448,"about_ca_system_score_gemma":0.00009398058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295666,"about_ca_topic_score_gemma":0.0001571602,"domain_scores_codex":[0.9977133,0.000340208,0.0005306921,0.0006723,0.0003707429,0.0003728065],"domain_scores_gemma":[0.9985425,0.0001670663,0.0005578356,0.0003559241,0.0001836774,0.0001930242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002104151,0.00008355275,0.3854679,0.00006909158,0.00007285857,0.00001994717,0.00064179,0.000009745775,0.6101951,0.0001134467,0.0007757253,0.002529836],"study_design_scores_gemma":[0.0005772384,0.00006333744,0.0368593,0.00003874698,0.0001276858,0.0001298836,0.0001229416,0.0008810567,0.9322781,0.002426357,0.0261793,0.0003160722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885612,0.0001816328,0.000005232439,0.0003980152,0.007295744,0.0007282863,0.00001424125,0.00006487862,0.002750763],"genre_scores_gemma":[0.9957273,0.00005830367,0.00005513718,0.0001329277,0.00007200726,0.00002217915,0.00001570067,0.00001539663,0.003901051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3486086,"threshold_uncertainty_score":0.7889674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0451432210386106,"score_gpt":0.3444397382877752,"score_spread":0.2992965172491646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}