{"id":"W2912609145","doi":"10.1093/nar/gkz069","title":"C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Institute of Genetics; Society for Anthropological Sciences; Institut National de la Santé et de la Recherche Médicale; Bpifrance","keywords":"Biology; Chinese hamster ovary cell; Polyadenylation; Cytoplasm; Cell biology; Polymerase; Molecular biology; DNA; T7 RNA polymerase; Gene expression; Computational biology; Gene; Genetics; Cell culture; Bacteriophage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002776913,0.0006054548,0.0004495689,0.0002930684,0.0003003279,0.0004852791,0.0006074032,0.0007198159,0.0007495511],"category_scores_gemma":[0.0002265752,0.0001706935,0.0003241443,0.0004093614,0.0003006794,0.0002532865,0.0004404058,0.0009151698,0.0008498941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008192515,"about_ca_system_score_gemma":0.0005095582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001245853,"about_ca_topic_score_gemma":0.0009266867,"domain_scores_codex":[0.9997703,0.00003192582,0.00001372835,0.00006653201,0.00007456343,0.00004289387],"domain_scores_gemma":[0.9998852,0.00001997429,0.00002007915,0.00001357142,0.00002714691,0.00003408035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000541593,0.00001005981,0.00008814639,0.00006478343,0.0000040061,0.00005147445,0.00001962912,0.0001420109,0.9963399,0.0003718465,0.0001720765,0.002681863],"study_design_scores_gemma":[0.000009182663,0.00008282189,0.0004464859,0.000004890177,0.00001087051,0.0002645094,0.0000059268,0.001748771,0.987789,0.00006680565,0.00955964,0.00001122685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7844113,0.004603534,0.1973348,0.0006039161,0.0002132588,0.0004450566,0.003405798,0.002158106,0.006824217],"genre_scores_gemma":[0.8611083,0.002969282,0.1183066,0.0001872629,0.0000350689,0.0002857796,0.008435417,0.0004398871,0.008232357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245853,"threshold_uncertainty_score":0.005944133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05332926539846407,"score_gpt":0.3323552813641752,"score_spread":0.2790260159657111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}