{"id":"W2912609145","doi":"10.1093/nar/gkz069","title":"C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Institute of Genetics; Society for Anthropological Sciences; Institut National de la Santé et de la Recherche Médicale; Bpifrance","keywords":"Biology; Chinese hamster ovary cell; Polyadenylation; Cytoplasm; Cell biology; Polymerase; Molecular biology; DNA; T7 RNA polymerase; Gene expression; Computational biology; Gene; Genetics; Cell culture; Bacteriophage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561757,0.0001762089,0.0002409857,0.000252439,0.0002260871,0.00005919617,0.0005638417,0.000277627,0.0003029461],"category_scores_gemma":[0.0001277288,0.000162691,0.0001167642,0.0003839337,0.0001896811,0.00001160351,0.0003268392,0.0003531386,0.0005448514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089683,"about_ca_system_score_gemma":0.000266442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003189078,"about_ca_topic_score_gemma":0.0001105611,"domain_scores_codex":[0.9969717,0.0004721158,0.0003681388,0.0005855546,0.0009866566,0.0006158381],"domain_scores_gemma":[0.9983278,0.00005448636,0.0000774517,0.0009462151,0.0004376487,0.0001563813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001442173,0.0001009094,0.003007819,0.0001605506,0.00003316021,0.00000527082,0.0001039172,0.0003337077,0.9904234,0.0001218497,0.002416514,0.001850734],"study_design_scores_gemma":[0.0006444946,0.002686185,0.000595559,0.00008104742,0.000004235869,0.00001008055,0.0002825241,0.004277499,0.9887784,0.00002512454,0.00244265,0.0001722377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954578,0.0003687461,0.0001714835,0.0001529014,0.0001752328,0.0006845344,0.00002275298,0.00002236825,0.002944223],"genre_scores_gemma":[0.9978443,0.000102982,0.000216713,0.00002202063,0.0004773912,0.00005830648,0.00009125747,0.00005751448,0.001129496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003943791,"threshold_uncertainty_score":0.7003144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05332926539846407,"score_gpt":0.3323552813641752,"score_spread":0.2790260159657111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}