{"id":"W2912617737","doi":"10.1016/j.jtho.2019.01.015","title":"Lung Adenocarcinoma Harboring EGFR 19del/C797S/T790M Triple Mutations Responds to Brigatinib and Anti-EGFR Antibody Combination Therapy","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario","funders":"National Natural Science Foundation of China","keywords":"Osimertinib; T790M; Medicine; Lung cancer; Acquired resistance; Adenocarcinoma; Pharmacology; Cancer research; Cancer; Epidermal growth factor receptor; Oncology; Internal medicine; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854143,0.000259638,0.0007283325,0.0002618323,0.0003508076,0.0003006356,0.0002036241,0.0004708244,0.001620745],"category_scores_gemma":[0.0004393727,0.00009527117,0.0004767106,0.0002273583,0.0001505442,0.0002096731,0.0001407173,0.0006721523,0.0008316142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004248757,"about_ca_system_score_gemma":0.0003870892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099591,"about_ca_topic_score_gemma":0.003640367,"domain_scores_codex":[0.9998446,0.00001824011,0.00001325164,0.00002342779,0.00003746335,0.00006315394],"domain_scores_gemma":[0.9998327,0.00004168212,0.00002188819,0.00001692132,0.00002773566,0.00005894974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.008826149,0.002051538,0.1433804,0.0005296965,0.0004146216,0.1806018,0.0003564254,0.005883233,0.2852232,0.0009164448,0.02414551,0.347671],"study_design_scores_gemma":[0.001106006,0.01005133,0.5905954,0.0001630033,0.0007823341,0.247522,0.001464561,0.01526359,0.05612289,0.003209621,0.07360824,0.0001111041],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657001,0.004934581,0.0014419,0.005227791,0.0005050909,0.0001968446,0.000611672,0.0002486494,0.02113337],"genre_scores_gemma":[0.9940801,0.0007507997,0.0004128713,0.001129367,0.0001546084,0.00001935219,0.0004641944,0.00001688292,0.002971673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620745,"threshold_uncertainty_score":0.005421937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02051283297441116,"score_gpt":0.4515014186261033,"score_spread":0.4309885856516922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}