{"id":"W2912634091","doi":"10.1016/j.isci.2019.02.008","title":"HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia; Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Environmental Health Sciences; Canadian Cancer Society Research Institute; National Cancer Institute; National Institutes of Health; Celgene; St. Baldrick's Foundation; Damon Runyon Cancer Research Foundation","keywords":"Acetylation; Ubiquitin; Ubiquitin ligase; Histone deacetylase 2; P300-CBP Transcription Factors; Mdm2; Histone; Chemistry; Cell biology; Bromodomain; Lysine; Histone deacetylase; Biology; Biochemistry; Histone Acetyltransferases; DNA; Apoptosis; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300627,0.0003912415,0.0002115977,0.0001782609,0.000226494,0.0004367942,0.0001782691,0.0002053628,0.002116875],"category_scores_gemma":[0.00007042773,0.0001355789,0.0002176901,0.0001469572,0.0002179009,0.0002529139,0.0002172977,0.0003531296,0.0005458702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004089247,"about_ca_system_score_gemma":0.000213073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003872978,"about_ca_topic_score_gemma":0.001100065,"domain_scores_codex":[0.9998853,0.00001820363,0.000006644439,0.00002402937,0.00002603021,0.00003979029],"domain_scores_gemma":[0.999964,0.00000291388,0.000009638607,0.000004005856,0.000005428479,0.00001399584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002087754,0.00003014437,0.0008300674,0.00004220881,0.000009337718,0.0001155017,0.00001361189,0.000122062,0.9940004,0.0007773567,0.000215304,0.003635217],"study_design_scores_gemma":[0.00003320072,0.0001722528,0.01454339,0.000009088645,0.00002237382,0.0004598776,0.0000687542,0.001544612,0.9720433,0.0003245711,0.01077116,0.000007398148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644995,0.01468118,0.007053407,0.0004770253,0.0001664374,0.00003956629,0.000672437,0.0002118822,0.01219857],"genre_scores_gemma":[0.9930359,0.001907625,0.0006856989,0.00004955341,0.00002431629,0.00001348645,0.0002586907,0.00001142501,0.004013251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002116875,"threshold_uncertainty_score":0.007081687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118653133698262,"score_gpt":0.2686181808143556,"score_spread":0.2567528674445294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}