{"id":"W2912635450","doi":"10.1111/adb.12720","title":"The role of DNA methyltransferase activity in cocaine treatment and withdrawal in the nucleus accumbens of mice","year":2019,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Indigenous and Northern Affairs Canada; Eesti Teadusagentuur","keywords":"Sensitization; Nucleus accumbens; Gene silencing; Methyltransferase; Behavioral sensitization; DNA methyltransferase; DNA methylation; DNMT1; Pharmacology; Chemistry; Psychology; Gene expression; Methylation; Neuroscience; Biology; Dopamine; DNA; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001942626,0.0006818547,0.0004960144,0.001037596,0.0003087172,0.0004731813,0.0004055467,0.0007248585,0.00144403],"category_scores_gemma":[0.0002346398,0.0004934579,0.0006206263,0.0002137954,0.0006712471,0.0004825957,0.0004093709,0.001381198,0.0004812183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000955375,"about_ca_system_score_gemma":0.0006281919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002175551,"about_ca_topic_score_gemma":0.005272163,"domain_scores_codex":[0.9996393,0.00003204993,0.00002889236,0.0001504798,0.00009019625,0.00005908268],"domain_scores_gemma":[0.9996678,0.00001557627,0.0001170851,0.00003012892,0.00003429319,0.0001350204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001613592,0.00002969871,0.0004962198,0.00001877321,0.000009063237,0.0000359246,0.00001789939,0.000021616,0.9980488,0.00006613409,0.00001591716,0.001078704],"study_design_scores_gemma":[0.00003609861,0.000624235,0.03055453,0.00002087616,0.0000517907,0.0003669116,0.00005189412,0.001068602,0.9656953,0.0001986312,0.00131405,0.00001703018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883251,0.003128236,0.004711383,0.0003593278,0.00006444721,0.0000924651,0.001268181,0.0002554507,0.001795383],"genre_scores_gemma":[0.9842477,0.001719337,0.005766729,0.0001689829,0.00001846648,0.0002559223,0.0009724352,0.0001584713,0.006691996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002175551,"threshold_uncertainty_score":0.006931722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006109068645064991,"score_gpt":0.2505008893772678,"score_spread":0.2443918207322028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}