{"id":"W2912649608","doi":"10.1016/j.omtm.2019.01.011","title":"Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Japan Society for the Promotion of Science; Waksman Foundation of Japan; Japan Agency for Medical Research and Development; Naito Foundation","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; SOX2; Progenitor cell; Molecular biology; Stem cell; PDX1; Interleukin 3; Embryonic stem cell; Homeobox protein NANOG; Cellular differentiation; Cell biology; KOSR; IL-2 receptor; Gene; Transcription factor; Immunology; Genetics; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001360592,0.0003394677,0.0007375794,0.00007563989,0.00007160506,0.00001728238,0.0004619416,0.0004239324,0.0002525066],"category_scores_gemma":[0.00006943052,0.0002837217,0.0002303582,0.0001927404,0.0001422968,0.00001122928,0.000154877,0.0002414127,0.00002056929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000355008,"about_ca_system_score_gemma":0.0001740021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004156589,"about_ca_topic_score_gemma":0.00000209661,"domain_scores_codex":[0.9956788,0.00125845,0.001304395,0.0008143918,0.0005535473,0.0003903921],"domain_scores_gemma":[0.9982488,0.000171834,0.0004187498,0.0008078127,0.0002096298,0.0001431566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003289518,0.0004556443,0.001532416,0.00005322953,0.0001933078,0.000003187266,0.0004410681,0.00002445641,0.9667339,0.000008062912,0.00007205959,0.03015371],"study_design_scores_gemma":[0.001513335,0.0007916128,0.00536004,0.00008205426,0.00001784989,7.3439e-7,0.0001221771,0.000002144069,0.9400546,0.0001263611,0.05163783,0.0002912692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9196295,0.002404752,0.07631868,0.00001992567,0.0004052206,0.001012371,0.00001690569,0.00001485792,0.0001778583],"genre_scores_gemma":[0.7048598,0.0008937808,0.293445,0.00003574887,0.00006024193,0.0000549174,0.0002237275,0.00005732148,0.0003694312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2171263,"threshold_uncertainty_score":0.9999615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07916198270621992,"score_gpt":0.4109332256513279,"score_spread":0.331771242945108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}