{"id":"W2912649608","doi":"10.1016/j.omtm.2019.01.011","title":"Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Japan Society for the Promotion of Science; Waksman Foundation of Japan; Japan Agency for Medical Research and Development; Naito Foundation","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; SOX2; Progenitor cell; Molecular biology; Stem cell; PDX1; Interleukin 3; Embryonic stem cell; Homeobox protein NANOG; Cellular differentiation; Cell biology; KOSR; IL-2 receptor; Gene; Transcription factor; Immunology; Genetics; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137292,0.0003640207,0.0002805673,0.0002260377,0.0001010308,0.000400225,0.0001878705,0.0001852093,0.001950726],"category_scores_gemma":[0.0002575937,0.0001883533,0.0003611596,0.0002785829,0.0002339488,0.0002509986,0.000241322,0.0009036,0.0007294189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001498055,"about_ca_system_score_gemma":0.0002850477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003353214,"about_ca_topic_score_gemma":0.0003811725,"domain_scores_codex":[0.999858,0.00001442913,0.00001405133,0.00004639291,0.00004039729,0.00002670704],"domain_scores_gemma":[0.9998156,0.00006676633,0.00003183144,0.00003646187,0.00002439898,0.00002489179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003088603,0.000007777668,0.0001892042,0.00002525794,0.000004362742,0.00004554344,0.00002271111,0.00007242247,0.9980179,0.0001235199,0.00002676807,0.001433617],"study_design_scores_gemma":[0.000005114402,0.00006839862,0.002348681,0.000007641009,0.00001801559,0.0001736467,0.00002208563,0.000426807,0.993839,0.0000625449,0.003025236,0.000002795539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9444951,0.001719191,0.0434993,0.0001616095,0.00007928771,0.0001550659,0.004675549,0.000440414,0.004774521],"genre_scores_gemma":[0.9646531,0.001499637,0.01776395,0.000123759,0.00002583568,0.0002654361,0.008917495,0.0002915162,0.006459331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001950726,"threshold_uncertainty_score":0.006525755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07916198270621992,"score_gpt":0.4109332256513279,"score_spread":0.331771242945108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}