{"id":"W2912664379","doi":"10.1002/jsp2.1045","title":"Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases","year":2019,"lang":"en","type":"review","venue":"JOR Spine","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Directorate for Biological Sciences; Engineering and Physical Sciences Research Council; National Institute for Health and Care Research; UK Regenerative Medicine Platform; Biotechnology and Biological Sciences Research Council; Rosetrees Trust; Medical Research Council Canada; University of Manchester","keywords":"Intervertebral disc; Degeneration (medical); Regeneration (biology); Context (archaeology); Cell biology; Mesenchymal stem cell; Extracellular matrix; Stem cell; Growth factor; Pathology; Medicine; Biology; Bioinformatics; Anatomy; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003176807,0.0002779262,0.001563874,0.0001867127,0.00001215494,0.000004541628,0.0001212854,0.0001306445,0.0001310455],"category_scores_gemma":[0.00002846999,0.0001253224,0.0007285951,0.0001795796,0.00005770076,0.00003288051,0.0000156829,0.00009175668,0.000007323081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007350008,"about_ca_system_score_gemma":0.00008822754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005806327,"about_ca_topic_score_gemma":0.00001486616,"domain_scores_codex":[0.9987573,0.0001582688,0.0005572034,0.0002154033,0.0001753569,0.0001364369],"domain_scores_gemma":[0.9992337,0.00001564563,0.0003604077,0.0003115492,0.00004892832,0.00002978105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00008839364,0.009755696,0.00717317,0.03764826,0.002839233,0.00008285259,0.00172553,0.000001868049,0.001757543,0.002557484,0.0004420154,0.9359279],"study_design_scores_gemma":[0.008747715,0.02858498,0.8242753,0.02159726,0.03418043,0.0000803878,0.0006994124,0.0001895319,0.003412819,0.00025406,0.07676464,0.001213441],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02331823,0.9748524,0.0001483386,0.00006534797,0.0002233082,0.001163017,0.0001408545,0.000006431828,0.00008201367],"genre_scores_gemma":[0.07508964,0.9235725,0.00002803292,0.00002594653,0.0001156159,0.0000696045,0.000756215,0.00002222962,0.0003201939],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9347145,"threshold_uncertainty_score":0.5110499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07655518289433874,"score_gpt":0.3681023224041047,"score_spread":0.291547139509766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}