{"id":"W2912665906","doi":"10.1182/blood-2018-99-119088","title":"Myelofibrosis Is Initiated and Sustained By Rare Multipotent Stem Cells","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Myelofibrosis; Myeloid; Biology; Progenitor cell; Haematopoiesis; Stem cell; Cancer research; Myeloproliferative neoplasm; Bone marrow; CD34; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629619,0.0002135837,0.0001618125,0.0002608802,0.0001918196,0.0002916318,0.0001164721,0.0001883704,0.001335538],"category_scores_gemma":[0.0001447983,0.00009186065,0.0001276459,0.0001317987,0.00016769,0.0001465564,0.0002987609,0.0002687254,0.0004369232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002152807,"about_ca_system_score_gemma":0.0001315082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002855707,"about_ca_topic_score_gemma":0.0004000999,"domain_scores_codex":[0.9998862,0.00001475715,0.00001077581,0.00002859311,0.00003816699,0.00002155335],"domain_scores_gemma":[0.9998432,0.00002547856,0.0000587982,0.00002162217,0.0000193998,0.00003141483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001995958,0.00002893244,0.01035238,0.00004300401,0.00000988714,0.0005764506,0.00005206906,0.000103651,0.9824716,0.000433847,0.0002211942,0.005507445],"study_design_scores_gemma":[0.00006861574,0.001066538,0.1113779,0.00004380858,0.00005575388,0.009047774,0.0001176738,0.002523768,0.856787,0.0005561574,0.01834263,0.00001237876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941842,0.000991423,0.002323858,0.00004015855,0.00001078826,0.00003846653,0.0004259325,0.0001332257,0.001851948],"genre_scores_gemma":[0.9970292,0.0002625687,0.001200651,0.000046237,0.000009230817,0.00002541698,0.0004954119,0.000009442702,0.0009218985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335538,"threshold_uncertainty_score":0.004467785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956427848632871,"score_gpt":0.2544280399630079,"score_spread":0.2348637614766792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}