{"id":"W2912715303","doi":"10.1111/jth.14404","title":"The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF‐dependent and independent manner","year":2019,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Von Willebrand factor; Internalization; Chemistry; Endocytic cycle; Mannose receptor; Receptor; Endocytosis; Chinese hamster ovary cell; Recombinant DNA; Cell biology; ADAMTS13; Molecular biology; In vitro; Immunology; Biology; Platelet; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005206211,0.0001599633,0.0004478929,0.0001826498,0.000127159,0.0001237653,0.00009701127,0.0001017754,0.0001757685],"category_scores_gemma":[0.00007062405,0.00009098191,0.00008597872,0.0001068318,0.0001293268,0.0001520087,0.00009944545,0.0004361265,0.00001082063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007543211,"about_ca_system_score_gemma":0.00007584914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000987759,"about_ca_topic_score_gemma":0.00007801504,"domain_scores_codex":[0.998587,0.00009588978,0.000404995,0.0001999293,0.0004459726,0.000266261],"domain_scores_gemma":[0.9992278,0.000181367,0.0001678849,0.0001377107,0.00009768241,0.000187507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003828182,0.0004500938,0.8300142,0.0002179991,0.0009141841,0.0001055615,0.002917532,0.000001343741,0.04027651,0.0002874565,0.001864555,0.1191224],"study_design_scores_gemma":[0.01229716,0.002884095,0.9335861,0.000894648,0.000186492,0.0007168581,0.00233411,0.00007867133,0.02664779,0.0002507608,0.01983074,0.0002926161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912232,0.002743132,0.000003231822,0.005024939,0.0002435503,0.0002904331,0.00001131214,0.000004483828,0.00045572],"genre_scores_gemma":[0.980454,0.01821739,0.000118497,0.0001360117,0.0001156962,0.000003605421,7.073988e-7,0.00001810814,0.0009359968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1188298,"threshold_uncertainty_score":0.3710134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04036470551970216,"score_gpt":0.3322925685410906,"score_spread":0.2919278630213885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}