{"id":"W2912715303","doi":"10.1111/jth.14404","title":"The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF‐dependent and independent manner","year":2019,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Von Willebrand factor; Internalization; Chemistry; Endocytic cycle; Mannose receptor; Receptor; Endocytosis; Chinese hamster ovary cell; Recombinant DNA; Cell biology; ADAMTS13; Molecular biology; In vitro; Immunology; Biology; Platelet; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003335913,0.0003646055,0.0003425177,0.0003656107,0.0002977949,0.0005639373,0.0005252265,0.0008338296,0.002940539],"category_scores_gemma":[0.000619763,0.000220443,0.0005274822,0.0001507125,0.0002805561,0.0003601683,0.0006111885,0.0007156838,0.001465338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001213386,"about_ca_system_score_gemma":0.0005065034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001299354,"about_ca_topic_score_gemma":0.001103958,"domain_scores_codex":[0.9993338,0.0001534678,0.00003720175,0.0001121554,0.000154545,0.000208855],"domain_scores_gemma":[0.9997141,0.00002946121,0.0000685276,0.00003696364,0.00009232634,0.00005854169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003121531,0.00005022124,0.001165205,0.00007743342,0.00003435809,0.0002693816,0.00001853644,0.0001051251,0.9916987,0.0005387606,0.001230723,0.004499382],"study_design_scores_gemma":[0.000148641,0.0003914907,0.03381518,0.00003275905,0.00004996997,0.00252312,0.00009337722,0.007951216,0.9321726,0.000392286,0.02239429,0.00003506953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971031,0.005021707,0.01111967,0.001430675,0.0002546316,0.000156942,0.000893422,0.0002744188,0.009817506],"genre_scores_gemma":[0.9732919,0.001315701,0.00617151,0.0006048873,0.0001122918,0.00008736069,0.001955724,0.00005025149,0.01641044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002940539,"threshold_uncertainty_score":0.009837091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04036470551970216,"score_gpt":0.3322925685410906,"score_spread":0.2919278630213885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}