{"id":"W2912728781","doi":"10.1182/blood-2018-99-118225","title":"Apoptotic Blocks in Primary Non-Hodgkin B-Cell Lymphomas Identified By BH3 Profiling","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hôpital Maisonneuve-Rosemont; BC Cancer Agency; Jewish General Hospital","funders":"","keywords":"Venetoclax; Mantle cell lymphoma; Cancer research; Apoptosis; MCL1; Lymphoma; Chronic lymphocytic leukemia; B cell; Biology; Gene expression profiling; Germinal center; Peripheral blood mononuclear cell; Immunology; Leukemia; Antibody; Gene expression; Downregulation and upregulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323641,0.000120383,0.0001178502,0.0002594116,0.0001365316,0.0001821004,0.0001171281,0.0001763269,0.001602595],"category_scores_gemma":[0.0001316516,0.00005936476,0.0001079071,0.0002090439,0.0001385231,0.0001472911,0.0001380499,0.0002560235,0.0003746454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221999,"about_ca_system_score_gemma":0.00007452019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003961507,"about_ca_topic_score_gemma":0.0004880664,"domain_scores_codex":[0.9998952,0.00001648484,0.000006241464,0.00001474629,0.00002946062,0.0000379182],"domain_scores_gemma":[0.9998946,0.00002362096,0.00002741663,0.00001128708,0.00002353203,0.00001957514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002610367,0.00001771675,0.001278798,0.00003321536,0.000003480344,0.00006355065,0.00001530873,0.00002244523,0.9961936,0.00002934717,0.00002268593,0.002058891],"study_design_scores_gemma":[0.00003013843,0.000688963,0.03949549,0.000006571369,0.00003266856,0.001188316,0.00005910556,0.0007524243,0.9555131,0.0000960091,0.002133455,0.0000036921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956559,0.001289432,0.00177548,0.00002696082,0.000006149751,0.00002707037,0.0002171916,0.00006338902,0.0009383693],"genre_scores_gemma":[0.9974808,0.0003344083,0.001127743,0.00002796736,0.0000041776,0.00001919813,0.0003835958,0.000007607789,0.0006144898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602595,"threshold_uncertainty_score":0.005361199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004260882046025065,"score_gpt":0.2100099568698639,"score_spread":0.2057490748238389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}