{"id":"W2912778251","doi":"10.1038/s41419-018-1294-2","title":"Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Seventh Framework Programme; Université de Montréal; Université Paris Descartes; Vrije Universiteit Amsterdam; European Commission; Amsterdam Neuroscience; Amsterdam University Medical Centers","keywords":"Downregulation and upregulation; SNAI1; Inflammation; Mesenchymal stem cell; Biology; Endothelial stem cell; Multiple sclerosis; Cell biology; Endothelial dysfunction; Blood–brain barrier; Neuroscience; Neuroprotection; Pathophysiology; Epithelial–mesenchymal transition; Immunology; Central nervous system; Endocrinology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242508,0.0002205637,0.0002507814,0.0003759551,0.0001786801,0.0002217995,0.00008712724,0.0003463523,0.000882033],"category_scores_gemma":[0.0001186148,0.0001139546,0.000192137,0.0001992082,0.0001949609,0.0002514573,0.0002285418,0.0005131219,0.0001919312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001424594,"about_ca_system_score_gemma":0.000132041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002612471,"about_ca_topic_score_gemma":0.0003278214,"domain_scores_codex":[0.9998871,0.0000232892,0.00001196237,0.00002502377,0.00002530165,0.00002741969],"domain_scores_gemma":[0.9999098,0.000006966099,0.00004320726,0.000005622434,0.00001382349,0.00002066206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00094057,0.00009073331,0.008381155,0.0002711932,0.00003979313,0.001842245,0.0002333102,0.00008692581,0.9775943,0.0004664434,0.0002226702,0.009830709],"study_design_scores_gemma":[0.0001007594,0.002114428,0.4127187,0.0001384441,0.0002202269,0.01449869,0.0007327095,0.002174144,0.5515406,0.002890402,0.01282805,0.00004287678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981202,0.01379451,0.003059322,0.0002459562,0.00005877828,0.00003455002,0.0002038265,0.0000930747,0.001307856],"genre_scores_gemma":[0.9943633,0.003465502,0.0009974124,0.0001025714,0.0000408806,0.00003075195,0.0001672517,0.000004734517,0.0008275753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000882033,"threshold_uncertainty_score":0.002950668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.018045441562526,"score_gpt":0.2077269259180602,"score_spread":0.1896814843555342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}