{"id":"W2912805658","doi":"10.1002/chin.201119210","title":"ChemInform Abstract: Discovery of MK‐7246, a Selective CRTH2 Antagonist for the Treatment of Respiratory Diseases.","year":2011,"lang":"en","type":"article","venue":"ChemInform","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Antagonist; Combinatorial chemistry; Respiratory system; Stereochemistry; Pharmacology; Internal medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812157,0.0009120604,0.0004869351,0.0005307971,0.00022643,0.0005582841,0.00055185,0.0005485396,0.009556244],"category_scores_gemma":[0.0001520884,0.0002884296,0.0002844992,0.0003387766,0.0001998667,0.0003530976,0.0003245986,0.0007496782,0.003755466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005596157,"about_ca_system_score_gemma":0.0007377386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007270472,"about_ca_topic_score_gemma":0.001455841,"domain_scores_codex":[0.9999082,0.00001162957,0.000004727113,0.0000175914,0.00003191555,0.00002585009],"domain_scores_gemma":[0.9999471,0.000004290049,0.00001169763,0.000003495317,0.00001169649,0.00002172191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003629222,0.000629476,0.000615916,0.002046989,0.0001301575,0.001518935,0.0001003361,0.002809354,0.8283012,0.005611714,0.02145786,0.1331489],"study_design_scores_gemma":[0.002880373,0.004856518,0.003140221,0.0001657351,0.000248229,0.002203383,0.00004468397,0.002122927,0.886066,0.0007420247,0.09745263,0.00007728337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6675971,0.07110526,0.04504957,0.006518343,0.003137833,0.00327035,0.02687574,0.002829178,0.1736166],"genre_scores_gemma":[0.8683572,0.03979399,0.0160224,0.002004422,0.0006760531,0.0005140579,0.01126553,0.0001046213,0.06126159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009556244,"threshold_uncertainty_score":0.03196877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02158768627346964,"score_gpt":0.2500833540488219,"score_spread":0.2284956677753522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}