{"id":"W2912809333","doi":"10.1158/2159-8290.cd-18-1448","title":"Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases","year":2019,"lang":"en","type":"letter","venue":"Cancer Discovery","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Synthetic lethality; Kinase; Mutant; Mutation; Lethality; Protein-Serine-Threonine Kinases; Cancer research; Computational biology; Biology; Genetics; Bioinformatics; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008927177,0.0004496776,0.0003904539,0.00006182768,0.00008610861,0.0001559919,0.0004470206,0.0005936821,0.0000425154],"category_scores_gemma":[0.00001997234,0.0003733481,0.0002039467,0.00009047444,0.0001831143,0.00001247734,0.0001785974,0.0006066033,0.00002567254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001057839,"about_ca_system_score_gemma":0.0005850171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002663198,"about_ca_topic_score_gemma":0.0001161051,"domain_scores_codex":[0.997984,0.00007713819,0.0002380641,0.0009040424,0.0002518329,0.0005449062],"domain_scores_gemma":[0.998701,0.00002830345,0.0002111367,0.0009488156,0.0000736994,0.00003700635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008378715,0.00004870365,0.002363049,0.0007128417,0.0001925678,0.00008043883,0.00003873697,0.0003236982,0.04832353,0.00002400287,0.9469908,0.0008177751],"study_design_scores_gemma":[0.0003322888,0.0001560465,0.0001349021,0.0003444562,0.000186182,0.00003330079,0.00003150688,0.00001697567,0.02218613,0.00001952563,0.9757905,0.0007681651],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.8622698,0.01897773,0.003038937,0.102084,0.002701981,0.001422264,0.002198924,0.00008795511,0.007218353],"genre_scores_gemma":[0.3446972,0.003276238,0.0001812533,0.6053337,0.006776554,0.0003566768,0.00365162,0.0003570468,0.03536972],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5175726,"threshold_uncertainty_score":0.9998719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009478920358585614,"score_gpt":0.2366424635059854,"score_spread":0.2271635431473998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}