{"id":"W2912809333","doi":"10.1158/2159-8290.cd-18-1448","title":"Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases","year":2019,"lang":"en","type":"letter","venue":"Cancer Discovery","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Synthetic lethality; Kinase; Mutant; Mutation; Lethality; Protein-Serine-Threonine Kinases; Cancer research; Computational biology; Biology; Genetics; Bioinformatics; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008221866,0.0006510392,0.000640231,0.0003025364,0.0006775154,0.0009259683,0.0005345881,0.007354026,0.002399013],"category_scores_gemma":[0.002096075,0.000202897,0.0004828677,0.0001918468,0.0008774574,0.0004399863,0.0002570339,0.00479213,0.00260995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001250082,"about_ca_system_score_gemma":0.0004112316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004742332,"about_ca_topic_score_gemma":0.0008696823,"domain_scores_codex":[0.9995254,0.0001117478,0.00005818881,0.00007655444,0.0001576397,0.0000704411],"domain_scores_gemma":[0.9988288,0.000767543,0.0001018428,0.00006660007,0.0001116644,0.0001235355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001233274,0.0002240168,0.002497009,0.0003169909,0.00008309903,0.06958079,0.0001377432,0.0005752475,0.03959688,0.01303962,0.793212,0.07950334],"study_design_scores_gemma":[0.001146335,0.001258722,0.007418708,0.0002494354,0.0001058,0.07398944,0.0002130671,0.004237064,0.04347122,0.02055015,0.8472379,0.0001221117],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03735538,0.01149474,0.00349972,0.8632386,0.03721978,0.0002309716,0.0007751019,0.0007114705,0.04547416],"genre_scores_gemma":[0.2211222,0.01416352,0.003111844,0.6219634,0.06443847,0.0003364123,0.0005481167,0.0002257594,0.07409022],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007354026,"threshold_uncertainty_score":0.009070039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009478920358585614,"score_gpt":0.2366424635059854,"score_spread":0.2271635431473998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}