{"id":"W2912834287","doi":"10.1002/glia.23592","title":"Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression","year":2019,"lang":"en","type":"article","venue":"Glia","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute on Aging; National Institutes of Health; Wellcome Trust; Eli Lilly and Company","keywords":"Neurodegeneration; Sting; Biology; Phenotype; Disease; Neuroscience; Interferon type I; Microglia; Interferon; Stimulator of interferon genes; Immunology; Inflammation; Innate immune system; Pathology; Medicine; Gene; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001551216,0.0004449087,0.0002191738,0.0002817648,0.0001230718,0.0002390713,0.0001125289,0.0002980917,0.0008384403],"category_scores_gemma":[0.00006973351,0.0001152774,0.0002682191,0.00009746898,0.0002250914,0.0002134927,0.000156997,0.0005556271,0.0002786254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002099848,"about_ca_system_score_gemma":0.0001109823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002651423,"about_ca_topic_score_gemma":0.0004515856,"domain_scores_codex":[0.9999074,0.00001413698,0.00001491762,0.00001748448,0.00001765321,0.00002840756],"domain_scores_gemma":[0.9998772,0.000006525615,0.00005011656,0.00001304639,0.00001535319,0.00003774772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001300289,0.00001615735,0.0005588065,0.00001962616,0.000002846338,0.00005119363,0.00001128716,0.00001285563,0.998676,0.00002717965,0.00001312511,0.0004808451],"study_design_scores_gemma":[0.00005023327,0.001573235,0.05076195,0.0000451165,0.00006748585,0.001105718,0.0001397745,0.001318848,0.9424347,0.0003500798,0.002142421,0.00001027614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996151,0.001504554,0.00139304,0.0000420192,0.00002072438,0.00002008914,0.0002125383,0.00005723206,0.0005987484],"genre_scores_gemma":[0.9966967,0.0007321816,0.001274562,0.00003462183,0.000013689,0.00002601353,0.0001821938,0.000007849942,0.001032183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008384403,"threshold_uncertainty_score":0.002804816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02564249575028435,"score_gpt":0.2688012017935724,"score_spread":0.2431587060432881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}