{"id":"W2912834287","doi":"10.1002/glia.23592","title":"Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression","year":2019,"lang":"en","type":"article","venue":"Glia","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute on Aging; National Institutes of Health; Wellcome Trust; Eli Lilly and Company","keywords":"Neurodegeneration; Sting; Biology; Phenotype; Disease; Neuroscience; Interferon type I; Microglia; Interferon; Stimulator of interferon genes; Immunology; Inflammation; Innate immune system; Pathology; Medicine; Gene; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001478136,0.0001846732,0.0001992399,0.00008392511,0.0001927095,0.00006394154,0.0001418779,0.0001331172,0.0009249534],"category_scores_gemma":[0.0001558144,0.0001585406,0.00004169314,0.00006793548,0.00007556479,0.0001673403,0.000141706,0.0002374961,0.0005967509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005177876,"about_ca_system_score_gemma":0.00008253042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002536324,"about_ca_topic_score_gemma":0.000006849809,"domain_scores_codex":[0.9988971,0.0002083182,0.000234271,0.0003354673,0.00003485912,0.0002899885],"domain_scores_gemma":[0.999494,0.00009163269,0.0001116637,0.0002091856,0.00006440711,0.00002912436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006731445,0.00002967159,0.001756835,0.00005033017,0.00003622222,0.000002589382,0.0001622483,0.000003985258,0.940161,0.00006980673,0.0001988753,0.05685533],"study_design_scores_gemma":[0.0006931444,0.0007567471,0.01045493,0.0003423757,0.00005616841,0.00001937954,0.00008091075,0.0003692944,0.9819828,0.0000181503,0.004908475,0.0003176687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911616,0.006661381,0.00004793941,0.0001418037,0.001288064,0.0002700055,0.000007293334,0.00007891985,0.0003429524],"genre_scores_gemma":[0.9980531,0.00005975518,0.00006821227,0.00009122073,0.0001154711,0.00001704658,0.00003640299,0.00002362873,0.001535102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05653766,"threshold_uncertainty_score":0.9999883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02564249575028435,"score_gpt":0.2688012017935724,"score_spread":0.2431587060432881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}