{"id":"W2912837122","doi":"10.3390/cells8020165","title":"Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation; Strong; Research Manitoba","keywords":"Epigenome; Histone; Ubiquitin; Biology; Epigenetics; Cell biology; Cancer epigenetics; Cancer research; Carcinogenesis; Epigenomics; Histone H2A; Histone methyltransferase; Cancer; Genetics; DNA methylation; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000211216,0.0002730796,0.0005608665,0.0001143665,0.00003237473,0.00002310149,0.00018958,0.0003766887,0.00004473151],"category_scores_gemma":[0.00001370269,0.000244119,0.0001658463,0.0001198179,0.00002651767,0.000003156933,0.00006990699,0.0001366813,0.00003235327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299298,"about_ca_system_score_gemma":0.0003015415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004186483,"about_ca_topic_score_gemma":0.0000516894,"domain_scores_codex":[0.9987749,0.0001168777,0.0003402107,0.0004147421,0.0001261637,0.0002271473],"domain_scores_gemma":[0.999343,0.00002256766,0.0002592213,0.0002886614,0.00005437067,0.00003213691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004411329,0.00002408682,0.00001798131,0.003198176,0.00006916004,0.000001755249,0.0001141011,0.0000170514,0.01018336,0.00003070491,0.0001855949,0.9861536],"study_design_scores_gemma":[0.0001381286,0.00002870541,0.00001722639,0.001357588,0.00006063408,4.210174e-7,0.00001895687,0.000003897283,0.0326227,0.00003263267,0.9653973,0.00032182],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001840045,0.9959468,0.0007152135,0.00002254247,0.0006001765,0.0005039666,0.0000270568,0.000007852523,0.000336397],"genre_scores_gemma":[0.0008322762,0.9960893,0.0004441717,0.00003980333,0.0001728551,0.0001244336,0.0005054784,0.00005533144,0.001736356],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9858318,"threshold_uncertainty_score":0.9954885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.104618962430695,"score_gpt":0.3756085679709364,"score_spread":0.2709896055402414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}