{"id":"W2912837122","doi":"10.3390/cells8020165","title":"Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation; Strong; Research Manitoba","keywords":"Epigenome; Histone; Ubiquitin; Biology; Epigenetics; Cell biology; Cancer epigenetics; Cancer research; Carcinogenesis; Epigenomics; Histone H2A; Histone methyltransferase; Cancer; Genetics; DNA methylation; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004476631,0.0007699075,0.0009137518,0.001654182,0.0002546648,0.0006561824,0.0008737618,0.001213105,0.00321679],"category_scores_gemma":[0.0004814064,0.0002483288,0.0004367518,0.001274096,0.0004208337,0.001061076,0.0006407761,0.001918078,0.001974042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006460266,"about_ca_system_score_gemma":0.0006583651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006273749,"about_ca_topic_score_gemma":0.001519009,"domain_scores_codex":[0.9998724,0.00002075431,0.0000140667,0.00002239795,0.00005259157,0.00001772591],"domain_scores_gemma":[0.9998543,0.00006783829,0.00001850642,0.000005901049,0.0000355345,0.00001797498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005967479,0.00007493616,0.0001097753,0.01186404,0.00007659399,0.0002443702,0.00004512039,0.0005036461,0.004387995,0.007144041,0.03392261,0.9415672],"study_design_scores_gemma":[0.00001218407,0.00008040275,0.0003404426,0.001412854,0.00005517069,0.0009597301,0.00002476738,0.00008914382,0.0008856735,0.002121035,0.9940069,0.00001173233],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001703898,0.996793,0.0003507402,0.000387126,0.0004028646,0.000007884005,0.00002082095,0.00001536717,0.001851952],"genre_scores_gemma":[0.0007851582,0.9974161,0.000298355,0.000292253,0.0001423795,0.000009177998,0.00003258575,0.000002487852,0.001021401],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00321679,"threshold_uncertainty_score":0.01076126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.104618962430695,"score_gpt":0.3756085679709364,"score_spread":0.2709896055402414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}