{"id":"W2912861074","doi":"10.1021/acschemneuro.9b00031","title":"T-Type Channel Druggability at a Crossroads","year":2019,"lang":"en","type":"review","venue":"ACS Chemical Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Druggability; Neuroscience; Channel (broadcasting); Calcium channel; Voltage-dependent calcium channel; Biology; N-type calcium channel; Computational biology; T-type calcium channel; Computer science; Medicine; Genetics; Calcium; Computer network; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001863071,0.0003409565,0.0005441005,0.00004850423,0.0001096699,0.00004720366,0.0005099643,0.0004538356,0.00001972509],"category_scores_gemma":[0.0004712629,0.0002837766,0.0002913869,0.0003701174,0.0002804901,0.000006337028,0.0005354058,0.0002211175,0.000156982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006501075,"about_ca_system_score_gemma":0.0001805345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001224301,"about_ca_topic_score_gemma":3.563487e-7,"domain_scores_codex":[0.9979011,0.00007144173,0.0003656206,0.001017096,0.0002751632,0.0003695935],"domain_scores_gemma":[0.9988361,0.0000295948,0.0001939038,0.0007056033,0.00009213554,0.000142633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002412629,0.0005637426,0.00004951905,0.01194438,0.00005547759,0.00001490001,0.00005666366,0.00008408455,0.5486833,0.00009903244,0.05062527,0.3875823],"study_design_scores_gemma":[0.0001057207,0.00007982153,0.000003878418,0.0001627191,0.00004071448,0.00005302087,9.186366e-7,0.00005401624,0.009525063,0.000008075018,0.9896616,0.0003044033],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004260625,0.9900627,0.00009524978,0.00004967882,0.003925097,0.0007326281,0.00005057688,0.00005328347,0.0007701743],"genre_scores_gemma":[0.002733523,0.989434,0.00001495877,0.0004218068,0.0005711891,0.00003583674,0.0003386417,0.00004617064,0.006403869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9390364,"threshold_uncertainty_score":0.9999614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06435319295843774,"score_gpt":0.3331457402446124,"score_spread":0.2687925472861746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}