{"id":"W2912861074","doi":"10.1021/acschemneuro.9b00031","title":"T-Type Channel Druggability at a Crossroads","year":2019,"lang":"en","type":"review","venue":"ACS Chemical Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Druggability; Neuroscience; Channel (broadcasting); Calcium channel; Voltage-dependent calcium channel; Biology; N-type calcium channel; Computational biology; T-type calcium channel; Computer science; Medicine; Genetics; Calcium; Computer network; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003983025,0.0005513481,0.0008822196,0.001097063,0.0002321257,0.0008868526,0.0007044228,0.001047476,0.002253796],"category_scores_gemma":[0.0003598726,0.000186405,0.0003036492,0.0009642555,0.0006425597,0.00149213,0.0006503822,0.002142501,0.001403926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006185704,"about_ca_system_score_gemma":0.0006440492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000556433,"about_ca_topic_score_gemma":0.0009660191,"domain_scores_codex":[0.9999051,0.0000160308,0.00001047338,0.00001873268,0.00003351799,0.0000160759],"domain_scores_gemma":[0.9998782,0.00005752723,0.00001345567,0.000005309651,0.00002952242,0.00001589965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008798121,0.00006906317,0.0001242009,0.01050226,0.00004500009,0.0004322855,0.00009555618,0.0006122987,0.00930138,0.03078753,0.04101275,0.9069298],"study_design_scores_gemma":[0.000009981169,0.00007075999,0.0002615193,0.001488574,0.00002323725,0.00103542,0.00003563666,0.0001160963,0.001244938,0.00581801,0.9898838,0.00001195405],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000241097,0.9970351,0.0002382156,0.0006174475,0.0002993538,0.000003224751,0.00001417339,0.00001157037,0.001539825],"genre_scores_gemma":[0.001557879,0.9965801,0.0002454165,0.0004285566,0.0002315962,0.000006663146,0.00001992574,0.000002792992,0.0009270707],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002253796,"threshold_uncertainty_score":0.00753969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06435319295843774,"score_gpt":0.3331457402446124,"score_spread":0.2687925472861746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}