{"id":"W2912868925","doi":"10.1158/2326-6074.cricimteatiaacr18-pr09","title":"Abstract PR09: Intratumoral delivery of engineered modified vaccinia virus Ankara expressing Flt3L and OX40L for \"in situ\" therapeutic cancer vaccination","year":2019,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Modified vaccinia Ankara; Vaccinia; Virology; Medicine; Cancer research; Immune system; Vaccination; IRF3; Genetic enhancement; ELISPOT; Immunotherapy; Cancer immunotherapy; Immunology; CD8; Cancer vaccine; Biology; Innate immune system; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316251,0.0004718922,0.0002884637,0.0001988621,0.0001170027,0.0002704266,0.0002719645,0.0005428745,0.001776727],"category_scores_gemma":[0.00006096692,0.0001329849,0.0003245624,0.0001129651,0.0002328815,0.0002363588,0.0001820075,0.0009027984,0.0006194291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003145477,"about_ca_system_score_gemma":0.0002535281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005876175,"about_ca_topic_score_gemma":0.0003299001,"domain_scores_codex":[0.9998177,0.00001674305,0.00001321576,0.00005409059,0.00003967309,0.00005854525],"domain_scores_gemma":[0.9999369,0.000006777829,0.00002127933,0.00000728614,0.000005842859,0.00002186884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001847597,0.00007224958,0.00004370585,0.00002898278,0.000003981761,0.00002875589,0.00000615791,0.00005947806,0.9981641,0.0001531982,0.00008701866,0.001167664],"study_design_scores_gemma":[0.00004845377,0.0007433795,0.0004698489,0.00000354216,0.00001480674,0.0002039365,0.00000520289,0.0008474262,0.9946812,0.00002727207,0.002951613,0.000003283917],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9806804,0.001271094,0.01276738,0.0002192201,0.0002554319,0.0002638626,0.001291859,0.000387061,0.002863611],"genre_scores_gemma":[0.9802419,0.0004774821,0.01168382,0.0000793391,0.00003820253,0.0001563646,0.00137255,0.00006337794,0.005886975],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001776727,"threshold_uncertainty_score":0.005943716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04892804453989135,"score_gpt":0.3722251005418337,"score_spread":0.3232970560019423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}