{"id":"W2912927195","doi":"10.1161/circ.132.suppl_3.19386","title":"Abstract 19386: The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap Syndrome” and a Common Therapy?","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"SIRT3; Medicine; Pulmonary fibrosis; Idiopathic pulmonary fibrosis; Pulmonary hypertension; Cancer research; Bleomycin; Fibrosis; Lung; Pathology; Mitochondrion; Pulmonary function testing; Pharmacology; Internal medicine; Sirtuin; Biology; Cell biology; NAD+ kinase; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004461971,0.0006890998,0.0007203649,0.0002833312,0.000292429,0.0006176305,0.0006092103,0.00112822,0.01041268],"category_scores_gemma":[0.000316195,0.0002131656,0.0004744661,0.0003580535,0.0007541282,0.0005546768,0.0005096421,0.001498188,0.002742723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004064076,"about_ca_system_score_gemma":0.0003969641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002394078,"about_ca_topic_score_gemma":0.0004651361,"domain_scores_codex":[0.9997775,0.00003685862,0.00002438256,0.00005148867,0.00007612116,0.00003359345],"domain_scores_gemma":[0.9997893,0.00002736242,0.00007123208,0.00001940647,0.00003208214,0.00006065444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008245504,0.0005606725,0.01029419,0.002830236,0.0004053115,0.003544809,0.0001736394,0.0003131187,0.7712657,0.004617544,0.0288965,0.1688527],"study_design_scores_gemma":[0.002200089,0.005505202,0.1162487,0.0006701971,0.001062461,0.02269712,0.0004618192,0.00255054,0.5603001,0.006352859,0.2818312,0.000119703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6706375,0.2066091,0.02397653,0.04216224,0.009176065,0.0003344969,0.004954043,0.002636026,0.039514],"genre_scores_gemma":[0.9241976,0.03474996,0.004250058,0.004698341,0.002809288,0.0001497695,0.003391099,0.0001258072,0.0256281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01041268,"threshold_uncertainty_score":0.03483385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04855482191167658,"score_gpt":0.2900144096850627,"score_spread":0.2414595877733861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}