{"id":"W2912983106","doi":"10.1128/mcb.00488-18","title":"E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair","year":2019,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Histone H2B; H3K4me3; Cell biology; Ubiquitin; DNA repair; Histone; Non-homologous end joining; Homologous recombination; Ubiquitin ligase; DNA damage; SUMO protein; DNA; Genetics; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002352143,0.0005961143,0.0002467819,0.0003120879,0.0001642661,0.0003267042,0.0002310949,0.0003369435,0.0009816085],"category_scores_gemma":[0.0001793389,0.0001427716,0.0002212387,0.0001284568,0.0002281201,0.0002697228,0.000283375,0.000230871,0.0004342189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004588187,"about_ca_system_score_gemma":0.0001879244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006251149,"about_ca_topic_score_gemma":0.0008940886,"domain_scores_codex":[0.9997992,0.00002683966,0.00002105328,0.00005113491,0.00006043978,0.00004132321],"domain_scores_gemma":[0.999788,0.000019257,0.00007694408,0.00002057175,0.00001798528,0.00007720516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004602302,0.00000619293,0.00039414,0.00001517117,0.000003566227,0.00004493637,0.000004427023,0.00001975853,0.9987738,0.00005240923,0.00001191303,0.0006276106],"study_design_scores_gemma":[0.00001403772,0.0001572559,0.02598703,0.000005096563,0.00002085551,0.001385844,0.00002691568,0.001110622,0.9674001,0.0001377758,0.003747999,0.000006355103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903011,0.003888512,0.003997861,0.00009366668,0.00002064483,0.00001383419,0.0004480497,0.0001807154,0.00105558],"genre_scores_gemma":[0.9940298,0.0009130662,0.00226413,0.00004144652,0.000008723388,0.00001842315,0.0009010192,0.00003169144,0.00179166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009816085,"threshold_uncertainty_score":0.003328979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250195269558296,"score_gpt":0.3034982529551896,"score_spread":0.27847872599936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}