{"id":"W2913029651","doi":"10.1016/j.bpj.2018.11.2078","title":"Triggered Calcium Events Reveal Electrophysiological Alterations in a Cohort of Patients Susceptible to Malignant Hyperthermia","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Malignant hyperthermia; Halothane; Stimulation; Caffeine; Chemistry; Internal medicine; Endocrinology; Ryanodine receptor; Calcium; Depolarization; Electrophysiology; Medicine; Neuroscience; Anesthesia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009210924,0.000288035,0.0004637643,0.0006146582,0.0005369651,0.0005551919,0.0001826114,0.0003827467,0.002107428],"category_scores_gemma":[0.0009646675,0.0001707365,0.0002380798,0.0004667331,0.0002919621,0.0003389759,0.0003575781,0.0004564508,0.0003968121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009792631,"about_ca_system_score_gemma":0.0001299116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005421408,"about_ca_topic_score_gemma":0.0005182158,"domain_scores_codex":[0.9998779,0.00001274562,0.00001337481,0.00004025756,0.00001953696,0.00003615254],"domain_scores_gemma":[0.9995727,0.00008504224,0.0001400557,0.000040099,0.00002740284,0.0001347029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005918437,0.00008324387,0.9870516,0.000009486041,0.00003162234,0.002810349,0.0002849919,0.00005649864,0.00696333,0.00005361231,0.00008375974,0.001979587],"study_design_scores_gemma":[0.000008437872,0.000360983,0.992675,0.000003472357,0.00003046083,0.005828973,0.0003897183,0.0001489469,0.0002818603,0.00006567358,0.0002003738,0.000006103127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994642,0.00006947941,0.0000717796,0.00002664235,0.000004547999,0.000003629669,0.00005964852,0.000003114222,0.0002970073],"genre_scores_gemma":[0.9996969,0.00004150859,0.00001919384,0.00001819017,0.00001283371,0.000003331133,0.00009267787,0.000001827157,0.0001135205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002107428,"threshold_uncertainty_score":0.007050097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153080038131704,"score_gpt":0.2494082824838213,"score_spread":0.2378774821025042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}