{"id":"W2913067630","doi":"10.1093/cid/ciz136","title":"Insertion as a Resistance Mechanism Against Integrase Inhibitors in Several Retroviruses","year":2019,"lang":"en","type":"letter","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institutes of Health","keywords":"Integrase; Medicine; Mechanism (biology); Integrase inhibitor; Virology; Genetics; Computational biology; Human immunodeficiency virus (HIV); Biology; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002483537,0.000553455,0.0008202103,0.0005515227,0.001810939,0.002961839,0.0009402453,0.03393957,0.002048042],"category_scores_gemma":[0.009641571,0.0005359172,0.001019117,0.0004672694,0.002392932,0.002034459,0.0009107983,0.01477805,0.001079611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002629986,"about_ca_system_score_gemma":0.0009406763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027961,"about_ca_topic_score_gemma":0.001396609,"domain_scores_codex":[0.9974623,0.0009387834,0.000310187,0.0002444742,0.0006964676,0.0003477398],"domain_scores_gemma":[0.9950729,0.00348934,0.0006428543,0.0001935465,0.0003189414,0.0002824231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001668127,0.0006270478,0.0140387,0.0006900711,0.000200523,0.2826217,0.004287019,0.001408122,0.02832326,0.06468426,0.4763487,0.1251024],"study_design_scores_gemma":[0.0009700205,0.001467882,0.00536161,0.0006181938,0.0002175987,0.1807726,0.001484284,0.004927143,0.01207976,0.03121804,0.7607392,0.0001436781],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04229939,0.00850406,0.002260607,0.9105859,0.01159283,0.00007863173,0.00006451653,0.0001045807,0.02450954],"genre_scores_gemma":[0.2408409,0.005957071,0.003123965,0.6827677,0.04636532,0.0001027598,0.00004405518,0.0000852168,0.02071301],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03393957,"threshold_uncertainty_score":0.01908195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315738672305654,"score_gpt":0.3227349820827932,"score_spread":0.2995775953597367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}