{"id":"W2913093012","doi":"10.1111/bcpt.13208","title":"Identifying factors affecting the pharmacokinetics of voriconazole in patients with liver dysfunction: A population pharmacokinetic approach","year":2019,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Central South University","keywords":"Voriconazole; Pharmacokinetics; Medicine; Pharmacology; CYP2C19; Bioavailability; Population; Volume of distribution; Internal medicine; Antifungal; Cytochrome P450; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001351742,0.0004160096,0.0008726943,0.0008466605,0.0002400461,0.000689351,0.0002056457,0.0004108752,0.0009313346],"category_scores_gemma":[0.002489137,0.0001940432,0.0005207841,0.0006370337,0.0002108312,0.0004681674,0.0002494234,0.0005534036,0.0001754931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845709,"about_ca_system_score_gemma":0.0003831497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008267841,"about_ca_topic_score_gemma":0.0008309476,"domain_scores_codex":[0.9993929,0.0003627618,0.00003828056,0.00008774574,0.00008214611,0.00003615483],"domain_scores_gemma":[0.9988099,0.00066011,0.0002438554,0.00007409001,0.0001379624,0.00007404332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001314304,0.0003488927,0.96235,0.00007131655,0.0004711236,0.0004570566,0.0001821736,0.002551568,0.005296529,0.0001409826,0.0003391394,0.0264769],"study_design_scores_gemma":[0.00009239622,0.002449384,0.9618104,0.00002364158,0.0004123631,0.001750423,0.0004260382,0.02905483,0.002245818,0.0006104226,0.001092931,0.00003136466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891418,0.001206786,0.008360346,0.0002248295,0.00001027973,0.00006641866,0.0002550479,0.00005071127,0.0006838333],"genre_scores_gemma":[0.9980799,0.0001798196,0.001399986,0.00004775258,0.00001600266,0.00002485284,0.0001358589,0.000005116216,0.0001108267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351742,"threshold_uncertainty_score":0.007148802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0395434780954393,"score_gpt":0.3492527960026292,"score_spread":0.3097093179071899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}