{"id":"W2913153847","doi":"10.1016/j.bpj.2018.11.1341","title":"The Molecular Mechanisms of State Dependent hERG Blockade by Dofetilide","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"hERG; Dofetilide; Chemistry; Gating; Molecular dynamics; Biophysics; Repolarization; Anti-Arrhythmia Agents; Pharmacology; Potassium channel; Electrophysiology; Internal medicine; QT interval; Computational chemistry; Atrial fibrillation; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005190304,0.000461947,0.000506775,0.0002701547,0.000264385,0.001261057,0.0008134902,0.0007450187,0.002384498],"category_scores_gemma":[0.0005731597,0.0003368304,0.0005077795,0.0001212417,0.0005939108,0.001279827,0.0003391443,0.001170417,0.0004941287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007833861,"about_ca_system_score_gemma":0.0003432597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004509999,"about_ca_topic_score_gemma":0.0005630737,"domain_scores_codex":[0.9998086,0.00004324509,0.00001452342,0.00002551592,0.0000340291,0.00007399461],"domain_scores_gemma":[0.9998,0.00008629571,0.00005936948,0.0000228588,0.0000136148,0.00001795511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002317218,0.0003664718,0.002546605,0.0006002705,0.0002168879,0.003411156,0.0006162855,0.00525007,0.8583449,0.07977667,0.002952195,0.04360129],"study_design_scores_gemma":[0.001210551,0.004632325,0.1217448,0.0004902143,0.0007399075,0.01691272,0.001819857,0.07115138,0.6338729,0.08614815,0.06101005,0.0002672015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8906221,0.04453272,0.02745282,0.01074849,0.0005982966,0.0002292166,0.0009253238,0.0004872488,0.02440379],"genre_scores_gemma":[0.9880877,0.007910439,0.001114236,0.0003531048,0.0001177626,0.00004510302,0.0001998645,0.000008717293,0.002163026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002384498,"threshold_uncertainty_score":0.00797689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00334607997544764,"score_gpt":0.2267787666199955,"score_spread":0.2234326866445478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}