{"id":"W2913205231","doi":"10.14309/00000434-201710001-00598","title":"A Treat to Target Approach Decreases the Rate of CD-Related Adverse Outcomes versus a Clinical Approach in Patients With Moderate to Severely Active Crohnʼs Disease: Data From CALM 2017 ACG Governors Award for Excellence in Clinical Research","year":2017,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Hazard ratio; Azathioprine; Internal medicine; Clinical endpoint; Gastroenterology; Adverse effect; Randomization; Calprotectin; Adalimumab; Crohn's disease; Prednisone; Randomized controlled trial; Inflammatory bowel disease; Surgery; Confidence interval; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002311434,0.0004294254,0.001605694,0.0002689171,0.0002731487,0.0007811681,0.0003360185,0.0006237259,0.004372791],"category_scores_gemma":[0.003248828,0.0002088694,0.001739111,0.0003655337,0.0004727215,0.0006923114,0.0004357143,0.001522569,0.0003840414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003743889,"about_ca_system_score_gemma":0.0007013435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005385805,"about_ca_topic_score_gemma":0.002269349,"domain_scores_codex":[0.9990373,0.0005906002,0.00007867659,0.0001025946,0.00009351349,0.00009731304],"domain_scores_gemma":[0.9971058,0.001135577,0.0006600633,0.0001713298,0.0001393085,0.0007879045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8769372,0.01102144,0.008982742,0.001049874,0.002719883,0.00005452789,0.00008623012,0.0003756622,0.002601785,0.0001317176,0.001874911,0.094164],"study_design_scores_gemma":[0.4600127,0.4038549,0.1267543,0.0002901279,0.003648577,0.0001666697,0.0001392234,0.0008123207,0.0009247553,0.0003464335,0.003004909,0.00004499199],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866471,0.008017016,0.0002299966,0.0010973,0.0002734775,0.000395642,0.0004641856,0.00003351555,0.002841803],"genre_scores_gemma":[0.9928053,0.003429838,0.0006622341,0.0009581842,0.0003950238,0.0002830127,0.0006042616,0.000009735055,0.0008523661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004372791,"threshold_uncertainty_score":0.01462847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07322241805630697,"score_gpt":0.3867399970764887,"score_spread":0.3135175790201817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}