{"id":"W2913237306","doi":"10.1016/j.eururo.2019.01.026","title":"Higher Risk of Fragility Fractures in Prostate Cancer Patients Treated with Combined Radium-223 and Abiraterone: Prednisone May Be the Culprit","year":2019,"lang":"en","type":"letter","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Medicine; Abiraterone; Prednisone; Prostate cancer; Radium-223; Urology; Abiraterone acetate; Oncology; Internal medicine; Culprit; Cancer; Bone metastasis; Androgen deprivation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000317803,0.000415404,0.000750012,0.0001697659,0.00007064575,0.0000211697,0.0002182294,0.0002474073,0.0002794876],"category_scores_gemma":[0.00003820029,0.0002180273,0.00007175561,0.0001832989,0.0005983803,0.00004571851,0.0001371644,0.001759191,0.00002894224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001011635,"about_ca_system_score_gemma":0.0001143728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000869792,"about_ca_topic_score_gemma":0.00004509934,"domain_scores_codex":[0.9969077,0.001127432,0.0004187233,0.0006501823,0.0003613065,0.0005346182],"domain_scores_gemma":[0.9986244,0.0002216945,0.00032522,0.0005973904,0.000165791,0.00006550113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004461928,0.0002887468,0.8476908,0.0002979261,0.00054471,0.0006055691,0.0006023464,0.000008040263,0.00004674091,7.683374e-7,0.1444501,0.001002365],"study_design_scores_gemma":[0.009645587,0.002677446,0.7252854,0.00007925704,0.0003318389,0.000006517387,0.00000624434,0.000009408075,0.0001447176,0.000005580444,0.2616258,0.0001821912],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8303425,0.002153855,3.312954e-7,0.1629113,0.0001637287,0.00184755,0.0003671588,0.00003501946,0.002178512],"genre_scores_gemma":[0.8993489,0.001625972,0.00001015096,0.08351862,0.0003254759,0.00008814445,0.0009128957,0.0001332318,0.01403657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1224054,"threshold_uncertainty_score":0.8890897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350445103717494,"score_gpt":0.2667152615062187,"score_spread":0.2532108104690437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}