{"id":"W2913239114","doi":"10.1038/s41562-019-0544-3","title":"Questioning the proposed translational pathway for germline genome editing","year":2019,"lang":"en","type":"article","venue":"Nature Human Behaviour","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Genome editing; Germline; CRISPR; Genome; Genetics; Biology; World Wide Web; Computational biology; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002953875,0.0005824094,0.0006644919,0.0004584191,0.001100671,0.00297829,0.001746791,0.003023422,0.005770587],"category_scores_gemma":[0.003840423,0.0003129767,0.0007508533,0.0002714047,0.003194605,0.003927199,0.001078558,0.005655906,0.0019148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001278133,"about_ca_system_score_gemma":0.002490188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007930717,"about_ca_topic_score_gemma":0.0009328577,"domain_scores_codex":[0.9991089,0.0001577767,0.00007700541,0.0002676506,0.0002091726,0.0001795539],"domain_scores_gemma":[0.9979513,0.0007509042,0.0002119196,0.0004674235,0.0002781395,0.0003403023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005273745,0.000206644,0.001529577,0.0006653205,0.00005278855,0.001764438,0.0005146222,0.003285944,0.3267809,0.6219574,0.004673569,0.03804145],"study_design_scores_gemma":[0.0002185889,0.00124859,0.003995865,0.0003801124,0.0001176611,0.003978351,0.001399561,0.03237469,0.4545923,0.396713,0.1047603,0.0002209891],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.3808772,0.01605404,0.4129891,0.09459586,0.007021354,0.0004088926,0.000999281,0.002629708,0.08442472],"genre_scores_gemma":[0.920139,0.00665532,0.05677246,0.003476603,0.0004222281,0.0001729413,0.0004116228,0.0002642997,0.01168554],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.005770587,"threshold_uncertainty_score":0.01930457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00584225822660125,"score_gpt":0.3005624991676628,"score_spread":0.2947202409410616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}