{"id":"W2913250121","doi":"10.1093/cid/ciz084","title":"Genome-wide Association Study Identifies Genetic Variants Associated With Early and Sustained Response to (Pegylated) Interferon in Chronic Hepatitis B Patients: The GIANT-B Study","year":2019,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"Stichting voor Lever- en Maag-Darm Onderzoek","keywords":"Medicine; HBeAg; Genome-wide association study; HBsAg; Pegylated interferon; Hepatitis B virus; Immunology; Hepatitis B; Internal medicine; Interferon; Virology; Gastroenterology; Genotype; Chronic hepatitis; Single-nucleotide polymorphism; Virus; Biology; Ribavirin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001427994,0.0003039369,0.0008044317,0.0002283728,0.0001986323,0.0001292358,0.0001428629,0.0001226449,0.00006520988],"category_scores_gemma":[0.01363927,0.0002189919,0.00009973325,0.000620416,0.00009846522,0.000159002,0.000259701,0.0004062056,0.0001093453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001421166,"about_ca_system_score_gemma":0.0002547726,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002840147,"about_ca_topic_score_gemma":0.0341751,"domain_scores_codex":[0.9955315,0.001821304,0.0009456672,0.0006605712,0.0005594406,0.0004815335],"domain_scores_gemma":[0.9947504,0.003624842,0.0003477233,0.0005042991,0.0005349293,0.0002377475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001394377,0.004416654,0.9903805,0.00002497699,0.0008590556,0.0001069101,0.002346676,0.00002543972,0.00001651725,4.048084e-7,0.0001062474,0.0003222032],"study_design_scores_gemma":[0.008295539,0.02279941,0.9673094,0.000156122,0.0005543584,3.505063e-7,0.0005512165,0.00003935208,6.241848e-7,0.00002499677,0.00002460222,0.0002440466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938189,0.000155516,0.000004964325,0.0003420526,0.0002983632,0.005152502,0.00004568791,0.0001273343,0.00005461381],"genre_scores_gemma":[0.9984095,0.00009874989,0.000001057921,0.0005311277,0.00008056554,0.0002829118,0.00002066946,0.00005137365,0.0005240495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03133496,"threshold_uncertainty_score":0.9946693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428231183706847,"score_gpt":0.3049593949406945,"score_spread":0.2906770831036261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}