{"id":"W2913257717","doi":"10.1016/j.abb.2019.01.004","title":"Isoniazid induces a monocytic-like phenotype in HL-60 cells","year":2019,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Taibah University; Canadian Institutes of Health Research; Alberta Innovates - Technology Futures","keywords":"Haematopoiesis; Cellular differentiation; Promyelocyte; Cell biology; MAPK/ERK pathway; CD14; K562 cells; Biology; Acute promyelocytic leukemia; Monocyte; Phenotype; Differentiation therapy; Myeloid; Chemistry; Stem cell; Leukemia; Cancer research; Immunology; Signal transduction; Cell culture; Biochemistry; Flow cytometry; Retinoic acid; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188658,0.0004335358,0.0005579271,0.0004080404,0.0003146401,0.0004191839,0.0002305867,0.000293974,0.001773911],"category_scores_gemma":[0.0001324665,0.0002240008,0.0004758285,0.0003903262,0.0002688281,0.000193267,0.0002760434,0.0009399582,0.001411848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668315,"about_ca_system_score_gemma":0.0002413966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064722,"about_ca_topic_score_gemma":0.001037089,"domain_scores_codex":[0.9996315,0.00006841309,0.00005184308,0.00004516563,0.00009910824,0.0001038953],"domain_scores_gemma":[0.9997324,0.00005173708,0.00003672825,0.00006571239,0.00004580535,0.00006764933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005365026,0.0001233447,0.000302699,0.00003914257,0.000004497609,0.0001983187,0.00003738581,0.00003057108,0.9979025,0.00007118409,0.0000631848,0.000690666],"study_design_scores_gemma":[0.00009096351,0.001514682,0.01186445,0.000008902993,0.00002047949,0.0004804381,0.0001354077,0.0003811673,0.9835944,0.00005136479,0.001850006,0.000007680036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901757,0.00129856,0.002538586,0.0002089848,0.0001624804,0.0001111669,0.001744322,0.000174819,0.003585253],"genre_scores_gemma":[0.991873,0.0007733289,0.001348632,0.0001510909,0.00006199852,0.00008375059,0.001967316,0.0000307664,0.003710131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001773911,"threshold_uncertainty_score":0.005934358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006068962071577851,"score_gpt":0.2284444544815527,"score_spread":0.2223754924099748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}