{"id":"W2913257717","doi":"10.1016/j.abb.2019.01.004","title":"Isoniazid induces a monocytic-like phenotype in HL-60 cells","year":2019,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Taibah University; Canadian Institutes of Health Research; Alberta Innovates - Technology Futures","keywords":"Haematopoiesis; Cellular differentiation; Promyelocyte; Cell biology; MAPK/ERK pathway; CD14; K562 cells; Biology; Acute promyelocytic leukemia; Monocyte; Phenotype; Differentiation therapy; Myeloid; Chemistry; Stem cell; Leukemia; Cancer research; Immunology; Signal transduction; Cell culture; Biochemistry; Flow cytometry; Retinoic acid; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006027781,0.0001881737,0.0002076426,0.00003634136,0.00002614315,0.00001518803,0.0002575392,0.0001533032,0.00001008917],"category_scores_gemma":[0.00001736771,0.0001749607,0.00009817781,0.0001207304,0.0002508382,0.00000428141,0.0002957208,0.0001741593,0.000008265541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004774476,"about_ca_system_score_gemma":0.00007589612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000352835,"about_ca_topic_score_gemma":0.000001652929,"domain_scores_codex":[0.9988894,0.000029008,0.0002068361,0.0004500826,0.0001338971,0.00029074],"domain_scores_gemma":[0.9994041,0.00002601944,0.00007249558,0.0003688064,0.00002520102,0.0001034175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001586276,0.000134948,0.000953062,0.000180498,0.00003360712,0.000003449299,0.00005551947,0.000006670741,0.9939415,0.00004234443,0.00003992506,0.00444984],"study_design_scores_gemma":[0.0006208019,0.0001677038,0.001004274,0.00005331388,0.000008088069,0.000003207773,0.0000803319,0.0001020412,0.9965295,0.0003903733,0.0008237608,0.0002166247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963846,0.0007978711,0.0000439105,0.00006876967,0.00004410522,0.0001535153,0.00003010771,0.00000606553,0.002471084],"genre_scores_gemma":[0.9978977,0.000418747,0.0005944573,0.00009969927,0.00007727262,0.000008287469,0.00008516622,0.00001729162,0.0008014009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004233216,"threshold_uncertainty_score":0.7134692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006068962071577851,"score_gpt":0.2284444544815527,"score_spread":0.2223754924099748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}