{"id":"W2913267557","doi":"10.1016/j.jconrel.2019.02.014","title":"Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma","year":2019,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé","keywords":"Melphalan; Retinoblastoma; Pharmacology; In vivo; Chemistry; microRNA; Gene delivery; Viability assay; Cancer research; Apoptosis; Drug; Cytotoxic T cell; In vitro; Genetic enhancement; Gene; Biology; Immunology; Multiple myeloma; Biotechnology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004867,0.0002766863,0.0002496256,0.0001660166,0.0001379349,0.0001900295,0.0001493382,0.0002957464,0.0004904771],"category_scores_gemma":[0.0000964867,0.0001306663,0.0002640324,0.00009979757,0.000150866,0.0002178068,0.0002184904,0.0002821946,0.0002130535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271516,"about_ca_system_score_gemma":0.00016778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004321002,"about_ca_topic_score_gemma":0.0007038976,"domain_scores_codex":[0.9998939,0.00001467668,0.000007990035,0.00002861696,0.0000366035,0.0000181557],"domain_scores_gemma":[0.9999642,0.000006637414,0.00001365519,0.000003489901,0.000005918771,0.000006012207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004666052,0.00001358182,0.00002751803,0.00003348693,0.000002910911,0.00002985072,0.00001007228,0.0001147753,0.9982929,0.00006806804,0.00002260935,0.001337663],"study_design_scores_gemma":[0.000007257931,0.0001260648,0.000193676,0.000002048135,0.000008463125,0.00006072797,0.000005845799,0.00114973,0.9973013,0.00001329914,0.00112806,0.000003570454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852203,0.002001088,0.01040312,0.00009985662,0.00006063632,0.00005914036,0.00008657106,0.0001052059,0.001964082],"genre_scores_gemma":[0.9886825,0.0008596176,0.007773564,0.00003580572,0.0000115064,0.00005544429,0.00006783026,0.00002748049,0.002486235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004904771,"threshold_uncertainty_score":0.001969993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006114412901805692,"score_gpt":0.2419309618444968,"score_spread":0.2358165489426911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}