{"id":"W2913273965","doi":"10.1038/s41467-019-08565-8","title":"Chaperone activation and client binding of a 2-cysteine peroxiredoxin","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Victoria","funders":"European Regional Development Fund; Natural Sciences and Engineering Research Council of Canada; Warren Y. Soper Charitable Trust; Fondation De Famille Alvin Segal; National Institute of General Medical Sciences; Jewish General Hospital; Leading Edge Endowment Fund; Genome British Columbia; Genome Canada; Fundação para a Ciência e a Tecnologia; McGill University; University of Victoria; Howard Hughes Medical Institute","keywords":"Chaperone (clinical); Peroxiredoxin; Dimer; Heat shock protein; Protein structure; Biochemistry; Protein folding; Chemistry; Cell biology; Plasma protein binding; Peroxidase; Biology; Biophysics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119694,0.0001649147,0.0001773049,0.00004669474,0.0002040132,0.0002597769,0.0002026157,0.000217368,0.001530572],"category_scores_gemma":[0.000136403,0.00009721473,0.0001750035,0.00006133582,0.000130012,0.0001978994,0.0002682983,0.0003410717,0.0003160296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003092422,"about_ca_system_score_gemma":0.0001457687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005377746,"about_ca_topic_score_gemma":0.0006468981,"domain_scores_codex":[0.9999194,0.000009885596,0.000002383233,0.00001953039,0.00002435046,0.00002445171],"domain_scores_gemma":[0.9999566,0.000005550306,0.000005825798,0.00000541563,0.00001059194,0.00001597168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001523443,0.00002581049,0.0008127913,0.00003621892,0.000006286082,0.0001808297,0.00007032116,0.000184888,0.9969,0.000315233,0.0001575816,0.00115778],"study_design_scores_gemma":[0.00003530382,0.0001604676,0.02055562,0.00001111975,0.000008191457,0.0005703815,0.0001634856,0.006318951,0.966926,0.0002191584,0.005018319,0.00001302903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976538,0.0002515411,0.001256896,0.00007363395,0.00001047332,0.000004304706,0.00002845246,0.00003788718,0.0006829764],"genre_scores_gemma":[0.9975193,0.000101779,0.0006411655,0.00003994411,0.000003375127,0.00000496988,0.0001133453,0.000006927886,0.001569182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530572,"threshold_uncertainty_score":0.005120218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164109909479231,"score_gpt":0.3157210712037164,"score_spread":0.2993100802557933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}