{"id":"W2913318194","doi":"10.1016/j.str.2019.01.002","title":"Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15","year":2019,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children; McGill University","funders":"Boehringer Ingelheim Stiftung; Ministry of Education - Singapore; National Research Foundation Singapore; Boehringer Ingelheim","keywords":"Deubiquitinating enzyme; Ubiquitin; Signal transducing adaptor protein; Cell biology; Dimer; Chemistry; Biology; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000414838,0.00008842071,0.0001179968,0.00002808018,0.00001821775,0.000004987099,0.00004733112,0.0001197421,0.0001939694],"category_scores_gemma":[0.00001490551,0.00007582075,0.00003400322,0.00004643006,0.00004951594,0.000004145887,0.00005197546,0.00005397777,6.616601e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002721161,"about_ca_system_score_gemma":0.00003497126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004510452,"about_ca_topic_score_gemma":0.00000231592,"domain_scores_codex":[0.9994776,0.00002486919,0.0001538493,0.0001627582,0.00009351523,0.00008737207],"domain_scores_gemma":[0.9996383,0.000003919375,0.0001212807,0.0001392331,0.00006851269,0.00002876347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006618847,0.000002661632,0.008535606,0.00006540407,0.0000190052,2.272897e-7,0.00006385061,0.000007448251,0.9893433,0.0006934843,0.00001659226,0.00118616],"study_design_scores_gemma":[0.00032517,0.0001382636,0.075642,0.00001448027,0.000007509289,0.00002031828,0.00002414556,0.00003294394,0.9224519,0.0002940864,0.0009661349,0.00008304702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990324,0.00007320676,0.00005542098,0.00002364685,0.0002267416,0.0001442059,0.0002093307,0.00000337266,0.0002316838],"genre_scores_gemma":[0.9991049,0.00000941031,0.0001833534,0.00004101455,0.0001542573,0.000001425698,0.0003759768,0.000007756391,0.0001219606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0671064,"threshold_uncertainty_score":0.3091881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006048246912567375,"score_gpt":0.200019720545416,"score_spread":0.1939714736328487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}