{"id":"W2913318992","doi":"10.1039/c8ra10303h","title":"Do soft anions promote protein denaturation through binding interactions? A case study using ribonuclease A","year":2019,"lang":"en","type":"article","venue":"RSC Advances","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ribonuclease; Chemistry; Folding (DSP implementation); Denaturation (fissile materials); Plasma protein binding; Crystallography; Biophysics; Stereochemistry; Biochemistry; RNA; Biology; Nuclear chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000414704,0.0003802244,0.000459914,0.0002288182,0.0007824163,0.0005239956,0.0002884953,0.0008551426,0.001213793],"category_scores_gemma":[0.0005443445,0.0001341246,0.0004194316,0.0002489269,0.0005153028,0.0005087519,0.0004778892,0.0006576772,0.0002172087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002879847,"about_ca_system_score_gemma":0.0001610635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216255,"about_ca_topic_score_gemma":0.001383052,"domain_scores_codex":[0.9997821,0.00007090935,0.000007359226,0.00003988937,0.00005325899,0.00004639629],"domain_scores_gemma":[0.9996203,0.0002279941,0.0000529482,0.00002083098,0.00004129352,0.0000365364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004141504,0.0003351021,0.004476756,0.0004838746,0.00007456872,0.00522641,0.0004540933,0.01132143,0.9656153,0.0024767,0.0004906951,0.008630834],"study_design_scores_gemma":[0.00006827924,0.001990487,0.006307848,0.00004800444,0.000100107,0.002303432,0.0006665196,0.06018543,0.9196796,0.002164735,0.00643564,0.00004991334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992435,0.002194841,0.002813146,0.00027362,0.00002126753,0.0000315469,0.000045095,0.00003631528,0.002149116],"genre_scores_gemma":[0.9938359,0.00140356,0.003103421,0.00005909118,0.00001733502,0.00001043659,0.00002489074,0.00001070951,0.001534717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216255,"threshold_uncertainty_score":0.004060507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374139758648443,"score_gpt":0.3113483439812998,"score_spread":0.2976069463948154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}