{"id":"W2913321668","doi":"10.1093/brain/awz019","title":"Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers","year":2019,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Health Sciences Centre; McGill University","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Genentech; Deutsches Zentrum für Neurodegenerative Erkrankungen; GHR Foundation; Avid Radiopharmaceuticals; Foundation for Barnes-Jewish Hospital; Medical Research Council; National Institute on Handicapped Research; National Institute on Aging; Alzheimer's Association; Hope Center for Neurological Disorders; Eli Lilly and Company; Foundation for the National Institutes of Health","keywords":"Dementia; Alzheimer's disease; Cognition; Neuroscience; Disease; Medicine; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002036003,0.0007201254,0.0005443097,0.0009198161,0.0003554544,0.0005585151,0.000293233,0.0004563457,0.0006375515],"category_scores_gemma":[0.003008369,0.0003548517,0.0003712713,0.0006568763,0.0003534358,0.0003919067,0.0004031355,0.0003885599,0.00009764452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004045781,"about_ca_system_score_gemma":0.0002941918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007291625,"about_ca_topic_score_gemma":0.00863345,"domain_scores_codex":[0.9996216,0.0001617066,0.00002641997,0.00009546107,0.00005629164,0.00003850034],"domain_scores_gemma":[0.9984201,0.0006952193,0.0004538145,0.0001395432,0.0001279837,0.0001633487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006340026,0.00004877972,0.9933808,0.00001764366,0.0002381124,0.0002242825,0.0001244753,0.0003974815,0.001404369,0.00003652317,0.00005350981,0.003439965],"study_design_scores_gemma":[0.000006545781,0.0001689819,0.997428,0.000005142951,0.00007403684,0.0005792152,0.00006146733,0.001165153,0.0002515857,0.0001483067,0.0001072058,0.00000425379],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989851,0.0005351852,0.0001512711,0.00002966605,0.000001800558,0.000002133771,0.00005791007,0.000003718655,0.0002331451],"genre_scores_gemma":[0.9994554,0.0001409078,0.0001679301,0.000009577651,0.000003217785,0.000002462549,0.00009417071,0.00000110787,0.0001252803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007291625,"threshold_uncertainty_score":0.01449835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02672320889731615,"score_gpt":0.3020309182733898,"score_spread":0.2753077093760736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}