{"id":"W2913321668","doi":"10.1093/brain/awz019","title":"Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers","year":2019,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Health Sciences Centre; McGill University","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Genentech; Deutsches Zentrum für Neurodegenerative Erkrankungen; GHR Foundation; Avid Radiopharmaceuticals; Foundation for Barnes-Jewish Hospital; Medical Research Council; National Institute on Handicapped Research; National Institute on Aging; Alzheimer's Association; Hope Center for Neurological Disorders; Eli Lilly and Company; Foundation for the National Institutes of Health","keywords":"Dementia; Alzheimer's disease; Cognition; Neuroscience; Disease; Medicine; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442783,0.0001295165,0.0001522248,0.000139993,0.0000548099,0.00002094422,0.0000352067,0.00002776255,0.0003940102],"category_scores_gemma":[0.000054304,0.00009676228,0.00003533676,0.0001808263,0.00009745648,0.00009755162,0.00002400557,0.00008356186,0.0001883895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002279899,"about_ca_system_score_gemma":0.0001951486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005925605,"about_ca_topic_score_gemma":0.0000451772,"domain_scores_codex":[0.998992,0.00007701651,0.0001389664,0.0002702291,0.0002579661,0.0002637906],"domain_scores_gemma":[0.9992847,0.000127862,0.00003935955,0.0001953148,0.00003514744,0.0003175667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001175463,0.0002773159,0.9935615,0.00004001686,0.002575488,0.0003906216,0.00005079733,6.643329e-7,0.00005834999,0.0004167115,0.001056471,0.0003965896],"study_design_scores_gemma":[0.005941492,0.000212886,0.9913126,0.0001973991,0.0007495574,0.00004741908,0.00009594217,0.0001692124,0.00007488074,0.0003192963,0.0007541221,0.000125255],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873746,0.006578263,0.00001187382,0.002398948,0.00002039215,0.001025303,0.00007352612,0.00003186597,0.002485218],"genre_scores_gemma":[0.9989724,0.00001265509,0.0002810679,0.0003510652,0.00002097766,0.00007185104,0.0001191386,0.00002499414,0.0001458647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01159778,"threshold_uncertainty_score":0.4314135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02672320889731615,"score_gpt":0.3020309182733898,"score_spread":0.2753077093760736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}