{"id":"W2913322643","doi":"10.1182/blood-2018-99-115370","title":"Slit-Robo Pathway Is Clinically Relevant and May Represent a Potential Target in Acute Promyelocytic Leukemia","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Acute promyelocytic leukemia; Cancer research; Arsenic trioxide; Annexin A5; Promyelocytic leukemia protein; Medicine; Bone marrow; Differentiation therapy; Cell growth; Cell cycle; Progenitor cell; Leukemia; Immunology; Stem cell; Apoptosis; Biology; Cell culture; Annexin; Internal medicine; Cancer; Cell biology; Flow cytometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553591,0.0002165885,0.0002707201,0.0001976309,0.000111467,0.0003324157,0.0001377409,0.0002165777,0.002506659],"category_scores_gemma":[0.0001828259,0.00004717653,0.000167615,0.0001655486,0.0001697654,0.0001936226,0.0001827987,0.0003829669,0.000331859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166422,"about_ca_system_score_gemma":0.0002587459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001440759,"about_ca_topic_score_gemma":0.0003288228,"domain_scores_codex":[0.9999429,0.00001639685,0.00000552398,0.000008778135,0.00001161022,0.00001490205],"domain_scores_gemma":[0.9999017,0.00001557796,0.00003944523,0.000004925223,0.00001303812,0.00002539313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005872923,0.0005248898,0.03382779,0.002877252,0.0002048517,0.004331663,0.0001209785,0.001313683,0.676663,0.003620745,0.006019616,0.2646225],"study_design_scores_gemma":[0.001106441,0.009451666,0.2206853,0.0008662522,0.0007473338,0.02949382,0.0006500948,0.006137491,0.4574274,0.007215336,0.2661562,0.00006262447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8585737,0.1197033,0.006225171,0.003468263,0.000222752,0.0001920475,0.0009312207,0.0004385955,0.01024502],"genre_scores_gemma":[0.9797192,0.01474356,0.001849039,0.0004640109,0.00009507034,0.00008398927,0.0005879918,0.00001249592,0.002444705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002506659,"threshold_uncertainty_score":0.008385658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007066961688592632,"score_gpt":0.2533104579737238,"score_spread":0.2462434962851312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}