{"id":"W2913336364","doi":"10.1016/j.cell.2019.01.025","title":"Widespread and Functional RNA Circularization in Localized Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":691,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Public Health Ontario; Health Sciences Centre; Sunnybrook Health Science Centre; Université Laval; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Center for Translational Molecular Medicine; Terry Fox Research Institute; University of Toronto; Canadian Cancer Society; Prostate Cancer Canada; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"Biology; Transcriptome; Circular RNA; RNA splicing; RNA; Polyadenylation; microRNA; RNA-Seq; Alternative splicing; Computational biology; Cancer; Prostate cancer; Non-coding RNA; Genetics; Cancer research; Gene; Gene expression; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004664717,0.00006885667,0.00006292771,0.00002443721,0.00001472568,0.00001303166,0.00003743578,0.00005945312,0.00008755888],"category_scores_gemma":[0.0000181068,0.00007168859,0.0000241964,0.00005092096,0.00002735576,0.000003033574,0.00004060849,0.00003553283,0.00001620983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001384446,"about_ca_system_score_gemma":0.00005641222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003273954,"about_ca_topic_score_gemma":0.00001968557,"domain_scores_codex":[0.9995068,0.00002242986,0.00008301208,0.0002164702,0.00006668259,0.0001046336],"domain_scores_gemma":[0.9997576,0.000004840401,0.00002889755,0.0001441029,0.00002767962,0.00003684939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005077244,0.00003295704,0.1216944,0.0000389895,0.000008355364,0.000001681431,0.00001771304,0.0006448549,0.8764468,0.00001760113,0.0003638658,0.0006820406],"study_design_scores_gemma":[0.002597191,0.00008043845,0.1448559,0.00004569106,0.00002408703,0.000005543539,0.00005977991,0.0007985847,0.8249565,0.0002629481,0.02599557,0.0003177311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952662,0.00269127,0.0003379455,0.00003692169,0.0001571486,0.0001867798,0.000010141,0.000005864233,0.001307728],"genre_scores_gemma":[0.9981804,0.0002420367,0.00003755579,0.0001888034,0.00004570236,0.00002322084,0.0001157831,0.00001264038,0.001153853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05149028,"threshold_uncertainty_score":0.2923376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005923573489320898,"score_gpt":0.2205344836584315,"score_spread":0.2146109101691106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}