{"id":"W2913356393","doi":"10.1161/circ.132.suppl_3.18705","title":"Abstract 18705: BRCA2 is a Novel Regulator of Endothelial Cell Function and Apoptosis","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"DNA damage; Gene silencing; Apoptosis; Cancer research; DNA repair; RAD51; TUNEL assay; Regulator; Medicine; Biology; Molecular biology; Cell biology; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188611,0.0003734992,0.0003447843,0.000287177,0.000276155,0.0005609481,0.0003627863,0.0004620424,0.005617985],"category_scores_gemma":[0.000169927,0.0001375119,0.0002919913,0.0002851934,0.0001596662,0.0002081685,0.0002333151,0.0006060769,0.001841192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004519919,"about_ca_system_score_gemma":0.0002761476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004153069,"about_ca_topic_score_gemma":0.0003135638,"domain_scores_codex":[0.999836,0.00002184728,0.00001277022,0.00005264485,0.00005574772,0.00002099452],"domain_scores_gemma":[0.9999021,0.00001247181,0.00003034073,0.00000732092,0.00001924367,0.00002854134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000855098,0.0001033477,0.002685841,0.0006767969,0.00007109705,0.001618027,0.00005029141,0.0002304977,0.9568387,0.001122896,0.007930674,0.02781666],"study_design_scores_gemma":[0.0002457922,0.0009778525,0.05467418,0.0001539581,0.0003000251,0.01376628,0.00009836951,0.003142064,0.7478701,0.0009358561,0.1777983,0.00003728441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8285183,0.09508659,0.02295087,0.004099946,0.002045847,0.0002340874,0.01673519,0.001932777,0.02839631],"genre_scores_gemma":[0.9207152,0.01319061,0.005618404,0.00103329,0.0005283963,0.000168748,0.01748954,0.0001183831,0.04113737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005617985,"threshold_uncertainty_score":0.018794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214639115800433,"score_gpt":0.2502145819904474,"score_spread":0.2280681908324431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}