{"id":"W2913393208","doi":"10.1016/j.jaip.2019.01.054","title":"Long-Term Outcomes with Subcutaneous C1-Inhibitor Replacement Therapy for Prevention of Hereditary Angioedema Attacks","year":2019,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre de Santé et de Services Sociaux de la Vieille-Capitale; Ottawa Allergy Research Corporation; McMaster University Medical Centre","funders":"Janssen Pharmaceuticals; Genentech; Grifols; Swedish Orphan Biovitrum; BioCryst; AbbVie; Celgene; Novartis; Meso Scale Diagnostics; U.S. Department of Defense; Sanofi; Arrowhead Pharmaceuticals; Merck; GlaxoSmithKline; Viropharma; School of Public Health, University of California Berkeley; Pfizer; CSL Behring; Shire; AstraZeneca; Alnylam Pharmaceuticals; Boehringer Ingelheim; Astellas Pharma US","keywords":"Hereditary angioedema; Medicine; Angioedema; C1-inhibitor; Term (time); MEDLINE; Intensive care medicine; Dermatology; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002632111,0.0002673189,0.000837621,0.0001836528,0.0003544592,0.000497933,0.0002490959,0.0005292075,0.001320716],"category_scores_gemma":[0.002381361,0.0001062523,0.0009494609,0.0002610982,0.0003242729,0.0004866871,0.0003043883,0.0008621698,0.0001481334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475838,"about_ca_system_score_gemma":0.0004607442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004091293,"about_ca_topic_score_gemma":0.000515602,"domain_scores_codex":[0.9991316,0.0004115885,0.00008096416,0.00009874535,0.0001413601,0.0001356561],"domain_scores_gemma":[0.9970282,0.0006689674,0.001268349,0.000177965,0.0001772241,0.0006793777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4222324,0.01676421,0.3503771,0.001059887,0.0041907,0.0005170697,0.0003001779,0.00173817,0.006142147,0.0002008312,0.002401518,0.1940757],"study_design_scores_gemma":[0.0333778,0.2666714,0.692287,0.000218863,0.002451633,0.0006317206,0.000157779,0.00104825,0.001353397,0.0001738094,0.001592833,0.00003542592],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950377,0.003717042,0.0001206156,0.0001268794,0.00002594988,0.00009821328,0.0002318442,0.000006968241,0.0006347712],"genre_scores_gemma":[0.99858,0.0006078505,0.00007724216,0.00009120432,0.00004917322,0.00005969432,0.0003808938,9.472738e-7,0.0001529656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002632111,"threshold_uncertainty_score":0.01392013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03321364454945547,"score_gpt":0.3698811433435542,"score_spread":0.3366674987940987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}