{"id":"W2913403354","doi":"10.1091/mbc.e18-05-0330","title":"PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation","year":2019,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Protein arginine methyltransferase 5; Cell biology; Stress granule; Methyltransferase; Methylation; Histone; Signal transduction; Translation (biology); Chromatin; Arginine; Biochemistry; Messenger RNA; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000979377,0.0003711786,0.000236525,0.0002480089,0.0002408396,0.0003380202,0.0001907057,0.0002998184,0.0007134326],"category_scores_gemma":[0.0001386298,0.0001106164,0.0002535762,0.0001677765,0.0002166609,0.0002059897,0.0002001602,0.0002894323,0.0004790325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250259,"about_ca_system_score_gemma":0.0001882673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000426787,"about_ca_topic_score_gemma":0.0006204064,"domain_scores_codex":[0.9999042,0.00001314905,0.000004439245,0.00002683394,0.00002927528,0.00002213296],"domain_scores_gemma":[0.999934,0.000007814688,0.00001979213,0.000006398767,0.00001491437,0.00001716775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008691744,0.00001070001,0.0007236599,0.0000298396,0.000005285343,0.0001199098,0.00001102697,0.00005726212,0.9965791,0.0001556328,0.00006238573,0.00215826],"study_design_scores_gemma":[0.00001361522,0.0001400408,0.01556487,0.000007321755,0.00001570349,0.0005178435,0.00004310664,0.001735476,0.9770203,0.0002186505,0.004716406,0.000006738173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800503,0.009042643,0.00754917,0.0002307454,0.00007975839,0.00003333413,0.0003972357,0.0001948369,0.002422003],"genre_scores_gemma":[0.9914094,0.00207815,0.002822423,0.00006629254,0.00002345262,0.00001545402,0.0007832986,0.00002355803,0.002778067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007134326,"threshold_uncertainty_score":0.002386689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006115727369748394,"score_gpt":0.2227791738561101,"score_spread":0.2166634464863617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}