{"id":"W2913456279","doi":"10.1038/s41375-019-0381-4","title":"Ibrutinib reprograms the glucocorticoid receptor in chronic lymphocytic leukemia cells","year":2019,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Ibrutinib; Chronic lymphocytic leukemia; Glucocorticoid receptor; Cancer research; Biology; Leukemia; Internal medicine; Glucocorticoid; Pharmacology; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001895352,0.0003347704,0.0002910091,0.0003272478,0.0003405658,0.0008854053,0.0003028204,0.0003547308,0.003363809],"category_scores_gemma":[0.0003073704,0.0001483208,0.0002726985,0.0003493164,0.0003624202,0.0002218096,0.0002695655,0.0009800694,0.00107255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009228254,"about_ca_system_score_gemma":0.0004496659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003356754,"about_ca_topic_score_gemma":0.00547875,"domain_scores_codex":[0.9996402,0.00006377192,0.00002226673,0.0000465726,0.00009285381,0.0001342934],"domain_scores_gemma":[0.9998572,0.00002025833,0.00003479812,0.00002985914,0.00001789539,0.00004003555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004498641,0.00005014695,0.001116035,0.00007116234,0.00002392029,0.000145552,0.00007029324,0.000219921,0.9888748,0.0005774513,0.001427415,0.006973455],"study_design_scores_gemma":[0.000354178,0.001156053,0.03190694,0.00004820546,0.00009330339,0.001517839,0.0007248839,0.00159807,0.8898354,0.0005076875,0.07222203,0.00003534056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751744,0.01009052,0.001825781,0.001503905,0.0004144342,0.00003161531,0.002151723,0.0004763514,0.008331237],"genre_scores_gemma":[0.9924536,0.001511621,0.0005180967,0.0002252698,0.00003983734,0.00001500006,0.0009665493,0.0000480519,0.004221837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003363809,"threshold_uncertainty_score":0.01125312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452921150416244,"score_gpt":0.2796821188064508,"score_spread":0.2651529073022884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}