{"id":"W2913514525","doi":"10.1007/s00228-019-02632-1","title":"Sex-by-formulation interaction in bioequivalence trials with transdermal patches","year":2019,"lang":"en","type":"review","venue":"European Journal of Clinical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"Bioequivalence; Transdermal; Medicine; Pharmacokinetics; Rivastigmine; Pharmacology; Transdermal patch; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.02724275,0.0008288938,0.006234952,0.0006580682,0.00009693927,0.00004459347,0.001186334,0.000657702,0.001701821],"category_scores_gemma":[0.0006465513,0.000590205,0.001702583,0.0004828719,0.0003101222,0.0003332471,0.0001435225,0.006060686,0.000343732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001128159,"about_ca_system_score_gemma":0.0007825535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001908394,"about_ca_topic_score_gemma":9.434968e-7,"domain_scores_codex":[0.9601115,0.03040417,0.00761822,0.0006890324,0.0004369934,0.0007401132],"domain_scores_gemma":[0.9846545,0.007696959,0.006479675,0.0002662882,0.0002784718,0.0006240531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001932073,0.0009772966,0.0001708821,0.00198146,0.001741675,0.0007857286,0.0001696414,0.0003205675,0.0004035384,0.000008138,0.0151997,0.9763093],"study_design_scores_gemma":[0.008574903,0.0009961791,0.00005680657,0.001148159,0.006832458,0.0003624267,0.00002847534,0.0001581018,0.0003404339,0.00001075921,0.9809098,0.0005814861],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005499066,0.9745198,0.0002897811,0.0003338372,0.01493204,0.001370435,0.0001902402,0.0000327227,0.002832092],"genre_scores_gemma":[0.01093989,0.9821295,0.00017753,0.001634325,0.004438463,0.00001738006,0.0000601565,0.0001488941,0.0004539096],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9757278,"threshold_uncertainty_score":0.9996549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.60535816344768,"score_gpt":0.6141343016009941,"score_spread":0.008776138153314128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}