{"id":"W2913534025","doi":"10.1128/aac.02112-18","title":"Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam","year":2019,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Manitoba; Public Health Agency of Canada","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Avibactam; Ceftazidime/avibactam; Biology; Computational biology; Chemistry; Pharmacology; Microbiology; Bacteria; Genetics; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001212978,0.0003620153,0.0002147814,0.0001665441,0.0002109559,0.0004862547,0.0004782006,0.0007223182,0.002753696],"category_scores_gemma":[0.0001459952,0.0001261533,0.0003381075,0.00008413826,0.0003096082,0.0002318904,0.0002004879,0.0008941551,0.000704596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006137567,"about_ca_system_score_gemma":0.0002862198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009523845,"about_ca_topic_score_gemma":0.0007218826,"domain_scores_codex":[0.9999145,0.00001126829,0.000005533055,0.00001596858,0.00002402526,0.00002865764],"domain_scores_gemma":[0.9999483,0.00001181761,0.00001353752,0.000004049287,0.000008732766,0.00001352085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000179859,0.0001470803,0.0006749911,0.0001109565,0.0000202185,0.0008169799,0.00001653694,0.0009141961,0.9900522,0.002950317,0.0003549824,0.003761794],"study_design_scores_gemma":[0.00009892508,0.0005191645,0.007378421,0.00001959644,0.00002643063,0.002019882,0.00003811502,0.006451224,0.9747263,0.0009835503,0.00772506,0.00001357735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571221,0.008638024,0.01467416,0.002368989,0.0004925049,0.0002286384,0.001174159,0.0003083193,0.01499299],"genre_scores_gemma":[0.993006,0.001205055,0.002818669,0.0002162142,0.00002889519,0.00002898251,0.0005700604,0.000009343699,0.002116784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002753696,"threshold_uncertainty_score":0.009212077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004480048418333542,"score_gpt":0.2218641727102278,"score_spread":0.2173841242918943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}