{"id":"W2913560514","doi":"10.1136/jim-2018-000962","title":"Targeting Cholesterol Metabolism in Glioblastoma: A New Therapeutic Approach in Cancer Therapy","year":2019,"lang":"en","type":"review","venue":"Journal of Investigative Medicine","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba","funders":"","keywords":"ABCA1; Cholesterol; Mevalonate pathway; Lipid raft; Cancer research; Cancer cell; Biology; Liver X receptor; LDL receptor; Cancer; Intracellular; Cell biology; Lipoprotein; Medicine; Endocrinology; Internal medicine; Transporter; Biochemistry; Nuclear receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000584263,0.0005332049,0.001016449,0.001067035,0.0003218876,0.001344098,0.0005357009,0.001081125,0.002670309],"category_scores_gemma":[0.0003165353,0.0001677699,0.0005052328,0.0006559041,0.0007516383,0.001589587,0.0008388155,0.002699079,0.001006844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009771,"about_ca_system_score_gemma":0.001113681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009307389,"about_ca_topic_score_gemma":0.003222654,"domain_scores_codex":[0.9998205,0.00004067876,0.00001185211,0.00002255257,0.0000640228,0.00004047931],"domain_scores_gemma":[0.9998411,0.00002978545,0.00002777811,0.0000114043,0.00004662534,0.00004331072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007054653,0.0006213468,0.00109817,0.003597538,0.0001779638,0.001179689,0.000227553,0.001052846,0.04315526,0.02757663,0.05112931,0.8694782],"study_design_scores_gemma":[0.0004583777,0.002283334,0.003624682,0.002248565,0.000310969,0.002858859,0.0002945891,0.002585103,0.01457714,0.02762346,0.9430464,0.00008863747],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009739285,0.953619,0.004593444,0.02310642,0.002004494,0.00005968368,0.000115525,0.0001608261,0.0066013],"genre_scores_gemma":[0.05317353,0.9285266,0.004641908,0.006226518,0.002163978,0.00007863275,0.0001831271,0.00002795231,0.004977804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002670309,"threshold_uncertainty_score":0.008933127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08200572813813048,"score_gpt":0.3493021992588174,"score_spread":0.2672964711206869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}