{"id":"W2913581799","doi":"10.1158/1078-0432.ccr-18-3205","title":"Tissue 2-Hydroxyglutarate as a Biomarker for <i>Isocitrate Dehydrogenase</i> Mutations in Gliomas","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Princess Margaret Cancer Foundation","keywords":"Isocitrate dehydrogenase; Glioma; Biomarker; IDH1; Medicine; Internal medicine; Pathology; Oncology; Mutation; Biology; Cancer research; Genetics; Enzyme; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005187258,0.0003560401,0.0002572837,0.0009495875,0.0001092127,0.0003975059,0.0001605594,0.0002445024,0.0005849738],"category_scores_gemma":[0.00100985,0.0001331183,0.0001321748,0.0003458684,0.000257013,0.0002050208,0.0001438136,0.0002482744,0.0002807115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867038,"about_ca_system_score_gemma":0.0001510468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005000121,"about_ca_topic_score_gemma":0.0005250458,"domain_scores_codex":[0.9997807,0.00007057127,0.00002288606,0.00004673327,0.00005352021,0.00002559349],"domain_scores_gemma":[0.999522,0.0001334776,0.0001591866,0.0000283795,0.00008976179,0.00006731854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002160005,0.00009266479,0.8787991,0.0000978153,0.0001108515,0.0003289513,0.00006817684,0.0004258378,0.1015184,0.0000369359,0.0001465582,0.01621465],"study_design_scores_gemma":[0.00005445283,0.001477464,0.8891882,0.00002603055,0.000211119,0.004490374,0.000161054,0.004851747,0.09871013,0.000115683,0.000694151,0.00001963892],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976987,0.001199722,0.0006222324,0.00002561728,0.000005131313,0.000008982446,0.00006574241,0.0000267262,0.0003471802],"genre_scores_gemma":[0.9989919,0.0001522559,0.0006767679,0.00001381125,0.000005425829,0.000005578377,0.00008514422,0.000002839857,0.00006626531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009495875,"threshold_uncertainty_score":0.002743304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2109262614718779,"score_gpt":0.550235907418832,"score_spread":0.3393096459469541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}