{"id":"W2913619269","doi":"10.1097/ju.0000000000000192","title":"Targeting the SHIP1 Pathway Fails to Show Treatment Benefit in Interstitial Cystitis/Bladder Pain Syndrome: Lessons Learned from Evaluating Potentially Effective Therapies in This Enigmatic Syndrome","year":2019,"lang":"en","type":"article","venue":"The Journal of Urology","topic":"Urinary Bladder and Prostate Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Bladder Pain Syndrome; Interstitial cystitis; Medicine; Internal medicine; Urinary system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004199441,0.0006602115,0.002492923,0.0001877035,0.0002788063,0.0007185627,0.0006247528,0.001127445,0.002153687],"category_scores_gemma":[0.002290505,0.0002724667,0.001045752,0.0002160353,0.001169352,0.0007230165,0.0002584326,0.001903122,0.0002243652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003276018,"about_ca_system_score_gemma":0.0008080397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001960228,"about_ca_topic_score_gemma":0.0006319396,"domain_scores_codex":[0.9991249,0.0005703517,0.00007405729,0.00007568491,0.0001025939,0.00005240281],"domain_scores_gemma":[0.9987398,0.0007245631,0.0002379643,0.00008166741,0.00007190455,0.0001440959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5640688,0.01565703,0.00884699,0.006571318,0.004747458,0.0006129419,0.0004740063,0.00416058,0.1101931,0.00106949,0.002220482,0.2813778],"study_design_scores_gemma":[0.506713,0.4588818,0.01588808,0.000389767,0.002061785,0.0004101678,0.0001189766,0.001859011,0.009054653,0.0006780054,0.003901315,0.00004354828],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677567,0.02628671,0.001563519,0.001706017,0.0002357418,0.00106726,0.0002065333,0.00004810983,0.001129441],"genre_scores_gemma":[0.9865729,0.0081137,0.002259451,0.0009810657,0.0004819026,0.000820253,0.0002481386,0.00001444117,0.0005081733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004199441,"threshold_uncertainty_score":0.02220905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0411588081405657,"score_gpt":0.33187127603533,"score_spread":0.2907124678947642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}