{"id":"W2913633350","doi":"10.1002/ajh.25425","title":"How we diagnose and manage altered oxygen affinity hemoglobin variants","year":2019,"lang":"en","type":"review","venue":"American Journal of Hematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Regional Laboratory Medicine Program; McMaster University; University of Toronto","funders":"","keywords":"P50; Hemoglobin; Oxygen–haemoglobin dissociation curve; Oxygen; Pathophysiology; Hemoglobin variants; Globin; Medicine; Chemistry; Gene; Computational biology; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004758305,0.0007408522,0.000895088,0.002319372,0.0003805254,0.001261891,0.0008249792,0.001525234,0.002273851],"category_scores_gemma":[0.001958996,0.0002078502,0.0004258832,0.001018776,0.0004753683,0.002379131,0.0005635864,0.002612234,0.002141226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005595183,"about_ca_system_score_gemma":0.001081758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001447177,"about_ca_topic_score_gemma":0.001762774,"domain_scores_codex":[0.9996976,0.00006898316,0.00006521068,0.00005371251,0.00008890568,0.00002570691],"domain_scores_gemma":[0.9994715,0.000217628,0.00008115096,0.00001665153,0.0001634942,0.00004970533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003980471,0.00006675781,0.00111753,0.007881177,0.00007998486,0.00254251,0.0001793086,0.0003281262,0.0009927074,0.003486248,0.0921762,0.8911096],"study_design_scores_gemma":[0.00002218219,0.00006925641,0.002989984,0.01454516,0.000184399,0.04332579,0.0004311911,0.0002537351,0.0006758395,0.008482561,0.9289682,0.00005162129],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004178999,0.9885176,0.00094188,0.005447847,0.001382093,0.00001348057,0.00003560859,0.00003962051,0.003203936],"genre_scores_gemma":[0.003022692,0.9896818,0.001524655,0.00277346,0.001888616,0.00001632511,0.00008464145,0.000007970928,0.0009998862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002319372,"threshold_uncertainty_score":0.007606804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02760063112227425,"score_gpt":0.3042322498232529,"score_spread":0.2766316187009787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}