{"id":"W2913653887","doi":"10.1021/acs.orglett.8b04093","title":"A Route to Polyprenol Pyrophosphate-Based Probes of <i>O</i>-Polysaccharide Biosynthesis in <i>Klebsiella pneumoniae</i> O2a","year":2019,"lang":"en","type":"article","venue":"Organic Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Chemistry; Glycan; Biosynthesis; Polysaccharide; Klebsiella pneumoniae; Pyrophosphate; Isocoumarin; Moiety; Stereochemistry; Biochemistry; Glycosylation; Gene; Escherichia coli; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001630276,0.0003620656,0.0005442799,0.0001221072,0.00003620883,0.00004535285,0.0005954278,0.0001882176,0.00264308],"category_scores_gemma":[0.000114929,0.0003692575,0.0001905788,0.000534792,0.00006904811,0.00009635091,0.0001107035,0.0002434581,0.0002775111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048917,"about_ca_system_score_gemma":0.0001240632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002309909,"about_ca_topic_score_gemma":0.00003152964,"domain_scores_codex":[0.9978924,0.00002714781,0.0005508918,0.000625484,0.0003517909,0.0005523081],"domain_scores_gemma":[0.9985121,0.0002384434,0.0001846496,0.0008842734,0.00003552586,0.0001450226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009389707,0.0001263125,0.0131003,0.0002890371,0.00004309391,0.0000327369,0.0002619725,0.0001072344,0.985176,0.000004118964,0.0003622926,0.0004029843],"study_design_scores_gemma":[0.0005950123,0.00001655642,0.0001722396,0.0002768009,0.00003901984,0.000005828849,0.0001192784,0.00009397932,0.9976008,0.000005800533,0.0006538759,0.0004208047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940012,0.00007756391,0.00002402076,0.004254378,0.0001005296,0.0001864986,0.00006219248,0.0000993572,0.001194315],"genre_scores_gemma":[0.9970289,0.00001109988,0.0001711467,0.0022659,0.00006702808,0.00003350688,0.00001038734,0.00008090094,0.000331131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01292806,"threshold_uncertainty_score":0.999876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004960523691679868,"score_gpt":0.1840093693713342,"score_spread":0.1790488456796543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}