{"id":"W2913763825","doi":"10.1002/chin.201045219","title":"ChemInform Abstract: Discovery of 4‐{1‐[({1‐ [4‐(Trifluoromethyl)benzyl]‐1H‐indol‐7‐yl}carbonyl)amino] cyclopropyl}benzoic Acid (MF‐766), a Highly Potent and Selective EP<sub>4</sub> Antagonist for Treating Inflammatory Pain.","year":2010,"lang":"en","type":"article","venue":"ChemInform","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Benzoic acid; Trifluoromethyl; Antagonist; Stereochemistry; Combinatorial chemistry; Medicinal chemistry; Organic chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009259659,0.0005822295,0.0002677637,0.0003607719,0.0001868244,0.0002733485,0.0003906174,0.000366287,0.009821913],"category_scores_gemma":[0.0001285311,0.0001761059,0.0001808544,0.0002248743,0.0001627841,0.0002332555,0.0002490361,0.0005264021,0.003204881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005727431,"about_ca_system_score_gemma":0.0006964118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00088969,"about_ca_topic_score_gemma":0.001466513,"domain_scores_codex":[0.9999403,0.000006303113,0.000002256038,0.00001110325,0.00002211433,0.00001782038],"domain_scores_gemma":[0.9999641,0.000003367403,0.000009517017,0.000002678071,0.00000721855,0.00001308626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009478187,0.000220201,0.0002573986,0.0006513337,0.00003099129,0.000556122,0.00004582366,0.0009664127,0.927017,0.002777978,0.004990592,0.06153839],"study_design_scores_gemma":[0.0004245614,0.001505346,0.002066542,0.00004931604,0.00006239842,0.0008328133,0.00001846118,0.0008173293,0.9388794,0.0003804997,0.05493868,0.00002459409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7865724,0.03247548,0.04008876,0.003521911,0.000881386,0.001155869,0.007774425,0.001254761,0.1262751],"genre_scores_gemma":[0.914853,0.01640229,0.01465457,0.0007067008,0.0002674042,0.0003030159,0.003868617,0.00005136932,0.04889297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009821913,"threshold_uncertainty_score":0.0328576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005882803477386141,"score_gpt":0.2221498725745289,"score_spread":0.2162670690971427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}